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Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5
The genome of influenza A virus (IAV) comprises eight RNA segments (vRNA) which are transcribed and replicated by the heterotrimeric IAV RNA-dependent RNA-polymerase (RdRp). RdRp consists of three subunits (PA, PB1 and PB2) and binds both the highly conserved 3′- and 5′-ends of the vRNA segment. The...
Autores principales: | Swale, Christopher, Monod, Alexandre, Tengo, Laura, Labaronne, Alice, Garzoni, Frédéric, Bourhis, Jean-Marie, Cusack, Stephen, Schoehn, Guy, Berger, Imre, Ruigrok, Rob WH, Crépin, Thibaut |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837377/ https://www.ncbi.nlm.nih.gov/pubmed/27095520 http://dx.doi.org/10.1038/srep24727 |
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