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Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells

Nedd4 family E3 ubiquitin ligases have been shown to restrict T-cell function and impact T-cell differentiation. We show here that Ndfip1 and Ndfip2, activators of Nedd4 family ligases, together limit accumulation and function of effector CD4+ T cells. Using a three-part proteomics approach in prima...

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Detalles Bibliográficos
Autores principales:	O'Leary, Claire E., Riling, Christopher R., Spruce, Lynn A., Ding, Hua, Kumar, Suresh, Deng, Guoping, Liu, Yuhong, Seeholzer, Steven H., Oliver, Paula M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837450/ https://www.ncbi.nlm.nih.gov/pubmed/27088444 http://dx.doi.org/10.1038/ncomms11226

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