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Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli

It is commonly assumed that neural systems efficiently process natural sensory input. However, the mechanisms by which such efficient processing is achieved, and the consequences for perception and behaviour remain poorly understood. Here we show that small conductance calcium-activated potassium (S...

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Autores principales: Huang, Chengjie G., Zhang, Zhubo D., Chacron, Maurice J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837484/
https://www.ncbi.nlm.nih.gov/pubmed/27088670
http://dx.doi.org/10.1038/ncomms11353
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author Huang, Chengjie G.
Zhang, Zhubo D.
Chacron, Maurice J.
author_facet Huang, Chengjie G.
Zhang, Zhubo D.
Chacron, Maurice J.
author_sort Huang, Chengjie G.
collection PubMed
description It is commonly assumed that neural systems efficiently process natural sensory input. However, the mechanisms by which such efficient processing is achieved, and the consequences for perception and behaviour remain poorly understood. Here we show that small conductance calcium-activated potassium (SK) channels enable efficient neural processing and perception of natural stimuli. Specifically, these channels allow for the high-pass filtering of sensory input, thereby removing temporal correlations or, equivalently, whitening frequency response power. Varying the degree of adaptation through pharmacological manipulation of SK channels reduced efficiency of coding of natural stimuli, which in turn gave rise to predictable changes in behavioural responses that were no longer matched to natural stimulus statistics. Our results thus demonstrate a novel mechanism by which the nervous system can implement efficient processing and perception of natural sensory input that is likely to be shared across systems and species.
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spelling pubmed-48374842016-05-04 Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli Huang, Chengjie G. Zhang, Zhubo D. Chacron, Maurice J. Nat Commun Article It is commonly assumed that neural systems efficiently process natural sensory input. However, the mechanisms by which such efficient processing is achieved, and the consequences for perception and behaviour remain poorly understood. Here we show that small conductance calcium-activated potassium (SK) channels enable efficient neural processing and perception of natural stimuli. Specifically, these channels allow for the high-pass filtering of sensory input, thereby removing temporal correlations or, equivalently, whitening frequency response power. Varying the degree of adaptation through pharmacological manipulation of SK channels reduced efficiency of coding of natural stimuli, which in turn gave rise to predictable changes in behavioural responses that were no longer matched to natural stimulus statistics. Our results thus demonstrate a novel mechanism by which the nervous system can implement efficient processing and perception of natural sensory input that is likely to be shared across systems and species. Nature Publishing Group 2016-04-18 /pmc/articles/PMC4837484/ /pubmed/27088670 http://dx.doi.org/10.1038/ncomms11353 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Huang, Chengjie G.
Zhang, Zhubo D.
Chacron, Maurice J.
Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli
title Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli
title_full Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli
title_fullStr Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli
title_full_unstemmed Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli
title_short Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli
title_sort temporal decorrelation by sk channels enables efficient neural coding and perception of natural stimuli
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837484/
https://www.ncbi.nlm.nih.gov/pubmed/27088670
http://dx.doi.org/10.1038/ncomms11353
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