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Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes

BACKGROUND: The clinical utility of primaquine (PQ), used as a racemic mixture of two enantiomers, is limited due to metabolism-linked hemolytic toxicity in individuals with genetic deficiency in glucose-6-phosphate dehydrogenase. The current study investigated differential metabolism of PQ enantiom...

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Detalles Bibliográficos
Autores principales:	Fasinu, Pius S., Avula, Bharathi, Tekwani, Babu L., Nanayakkara, N. P. Dhammika, Wang, Yan-Hong, Bandara Herath, H. M. T., McChesney, James D., Reichard, Gregory A., Marcsisin, Sean R., Elsohly, Mahmoud A., Khan, Shabana I., Khan, Ikhlas A., Walker, Larry A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837544/ https://www.ncbi.nlm.nih.gov/pubmed/27093859 http://dx.doi.org/10.1186/s12936-016-1270-1

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