Phage Peptide Libraries As a Source of Targeted Ligands

One of the dominant trends in modern pharmacology is the creation of drugs that act directly on the lesion focus and have minimal toxicity on healthy tissues and organs. This problem is particularly acute in relation to oncologic diseases. Short tissue- and organ-specific peptides capable of deliver...

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Autores principales: Nemudraya, A. A., Richter, V. A., Kuligina, E. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837571/
https://www.ncbi.nlm.nih.gov/pubmed/27099784
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author Nemudraya, A. A.
Richter, V. A.
Kuligina, E. V.
author_facet Nemudraya, A. A.
Richter, V. A.
Kuligina, E. V.
author_sort Nemudraya, A. A.
collection PubMed
description One of the dominant trends in modern pharmacology is the creation of drugs that act directly on the lesion focus and have minimal toxicity on healthy tissues and organs. This problem is particularly acute in relation to oncologic diseases. Short tissue- and organ-specific peptides capable of delivering drugs to the affected organ or tissue are considered promising targeted agents that can be used in the diagnosis and therapy of diseases, including cancer. The review discusses in detail the technology of phage display as a method for obtaining specific targeted peptide agents and offers examples of their use in diagnostic and clinical practice.
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spelling pubmed-48375712016-04-20 Phage Peptide Libraries As a Source of Targeted Ligands Nemudraya, A. A. Richter, V. A. Kuligina, E. V. Acta Naturae Research Article One of the dominant trends in modern pharmacology is the creation of drugs that act directly on the lesion focus and have minimal toxicity on healthy tissues and organs. This problem is particularly acute in relation to oncologic diseases. Short tissue- and organ-specific peptides capable of delivering drugs to the affected organ or tissue are considered promising targeted agents that can be used in the diagnosis and therapy of diseases, including cancer. The review discusses in detail the technology of phage display as a method for obtaining specific targeted peptide agents and offers examples of their use in diagnostic and clinical practice. A.I. Gordeyev 2016 /pmc/articles/PMC4837571/ /pubmed/27099784 Text en Copyright ® 2016 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nemudraya, A. A.
Richter, V. A.
Kuligina, E. V.
Phage Peptide Libraries As a Source of Targeted Ligands
title Phage Peptide Libraries As a Source of Targeted Ligands
title_full Phage Peptide Libraries As a Source of Targeted Ligands
title_fullStr Phage Peptide Libraries As a Source of Targeted Ligands
title_full_unstemmed Phage Peptide Libraries As a Source of Targeted Ligands
title_short Phage Peptide Libraries As a Source of Targeted Ligands
title_sort phage peptide libraries as a source of targeted ligands
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837571/
https://www.ncbi.nlm.nih.gov/pubmed/27099784
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