Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

BACKGROUND: The interferon-γ (IFN-γ)-inducible immunity-related GTPase (IRG), Irgm1, plays an essential role in restraining activation of the IRG pathogen resistance system. However, the loss of Irgm1 in mice also causes a dramatic but unexplained susceptibility phenotype upon infection with a varie...

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Detalles Bibliográficos
Autores principales: Maric-Biresev, Jelena, Hunn, Julia P., Krut, Oleg, Helms, J. Bernd, Martens, Sascha, Howard, Jonathan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837601/
https://www.ncbi.nlm.nih.gov/pubmed/27098192
http://dx.doi.org/10.1186/s12915-016-0255-4

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