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Population Pharmacokinetics of High-dose Methotrexate After Intravenous Administration in Chinese Osteosarcoma Patients from a Single Institution

BACKGROUND: High-dose methotrexate (HD-MTX) with folinic acid (leucovorin) rescue is the gold standard therapy in the treatment of osteosarcoma. The plasma concentration of MTX is closely related to efficacy and toxicity. There are large individual differences. Many authors have described the pharma...

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Detalles Bibliográficos
Autores principales:	Zhang, Wei, Zhang, Qing, Tian, Xiaohuang, Zhao, Haitao, Lu, Wei, Zhen, Jiancun, Niu, Xiaohui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837805/ https://www.ncbi.nlm.nih.gov/pubmed/25563323 http://dx.doi.org/10.4103/0366-6999.147829

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