Increased Orexin Expression Promotes Sleep/Wake Disturbances in the SOD1-G93A Mouse Model of Amyotrophic Lateral Sclerosis

BACKGROUND: Sleep/wake disturbances in patients with amyotrophic lateral sclerosis (ALS) are well-documented, however, no animal or mechanistic studies on these disturbances exist. Orexin is a crucial neurotransmitter in promoting wakefulness in sleep/wake regulation, and may play an important role...

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Detalles Bibliográficos
Autores principales: Liu, Rong, Sheng, Zhao-Fu, Cai, Bing, Zhang, Yong-He, Fan, Dong-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837845/
https://www.ncbi.nlm.nih.gov/pubmed/25591569
http://dx.doi.org/10.4103/0366-6999.149214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837845/
https://www.ncbi.nlm.nih.gov/pubmed/25591569
http://dx.doi.org/10.4103/0366-6999.149214

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