Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection

With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has...

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Autores principales: Houser, Katherine V., Gretebeck, Lisa, Ying, Tianlei, Wang, Yanping, Vogel, Leatrice, Lamirande, Elaine W., Bock, Kevin W., Moore, Ian N., Dimitrov, Dimiter S., Subbarao, Kanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837915/
https://www.ncbi.nlm.nih.gov/pubmed/26941283
http://dx.doi.org/10.1093/infdis/jiw080
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author Houser, Katherine V.
Gretebeck, Lisa
Ying, Tianlei
Wang, Yanping
Vogel, Leatrice
Lamirande, Elaine W.
Bock, Kevin W.
Moore, Ian N.
Dimitrov, Dimiter S.
Subbarao, Kanta
author_facet Houser, Katherine V.
Gretebeck, Lisa
Ying, Tianlei
Wang, Yanping
Vogel, Leatrice
Lamirande, Elaine W.
Bock, Kevin W.
Moore, Ian N.
Dimitrov, Dimiter S.
Subbarao, Kanta
author_sort Houser, Katherine V.
collection PubMed
description With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40–9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.
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spelling pubmed-48379152017-05-15 Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection Houser, Katherine V. Gretebeck, Lisa Ying, Tianlei Wang, Yanping Vogel, Leatrice Lamirande, Elaine W. Bock, Kevin W. Moore, Ian N. Dimitrov, Dimiter S. Subbarao, Kanta J Infect Dis Major Articles and Brief Reports With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40–9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336. Oxford University Press 2016-05-15 2016-03-03 /pmc/articles/PMC4837915/ /pubmed/26941283 http://dx.doi.org/10.1093/infdis/jiw080 Text en Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Major Articles and Brief Reports
Houser, Katherine V.
Gretebeck, Lisa
Ying, Tianlei
Wang, Yanping
Vogel, Leatrice
Lamirande, Elaine W.
Bock, Kevin W.
Moore, Ian N.
Dimitrov, Dimiter S.
Subbarao, Kanta
Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
title Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
title_full Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
title_fullStr Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
title_full_unstemmed Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
title_short Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
title_sort prophylaxis with a middle east respiratory syndrome coronavirus (mers-cov)–specific human monoclonal antibody protects rabbits from mers-cov infection
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837915/
https://www.ncbi.nlm.nih.gov/pubmed/26941283
http://dx.doi.org/10.1093/infdis/jiw080
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