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Targeted Therapy in Oropharyngeal Squamous Cell Carcinoma: The Implications of HPV for Therapy

Oropharyngeal cancers caused by human papillomaviruses (HPV) have a different epidemiology, prognosis, genetic mutational landscape, response to treatment, and outcome when compared to HPV-negative cancers. In this review, a summary of our current understanding of HPV in head and neck cancer and the...

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Detalles Bibliográficos
Autores principales: Hay, Ashley, Ganly, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837939/
https://www.ncbi.nlm.nih.gov/pubmed/27182480
http://dx.doi.org/10.1007/s40487-015-0008-5
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author Hay, Ashley
Ganly, Ian
author_facet Hay, Ashley
Ganly, Ian
author_sort Hay, Ashley
collection PubMed
description Oropharyngeal cancers caused by human papillomaviruses (HPV) have a different epidemiology, prognosis, genetic mutational landscape, response to treatment, and outcome when compared to HPV-negative cancers. In this review, a summary of our current understanding of HPV in head and neck cancer and the important advances that have shown HPV to be an etiological agent are discussed. HPV-positive and HPV-negative tumors are compared discussing clinicopathological factors, prognosis, outcome following treatment, and the molecular and genetic differences. Currently, the standard of care for oropharyngeal cancer is both surgery and post-operative radiotherapy with or without cisplatin or concurrent chemo-radiotherapy. The latter is used more often, especially in cancers of tonsil and base of tongue. However, there is increased interest in trying to de-intensify treatment and in the development of new treatments to target the underlying different molecular pathways of HPV-positive cancers. The current clinical trials involving surgery, chemotherapy, and radiation therapy are discussed. The new targeted treatments are also summarized. Although there is currently is no evidence from prospective studies to support a change in the treatment algorithm, the treatment options for patients with HPV-positive disease are likely to change in the future.
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spelling pubmed-48379392016-05-11 Targeted Therapy in Oropharyngeal Squamous Cell Carcinoma: The Implications of HPV for Therapy Hay, Ashley Ganly, Ian Rare Cancers Ther Review Oropharyngeal cancers caused by human papillomaviruses (HPV) have a different epidemiology, prognosis, genetic mutational landscape, response to treatment, and outcome when compared to HPV-negative cancers. In this review, a summary of our current understanding of HPV in head and neck cancer and the important advances that have shown HPV to be an etiological agent are discussed. HPV-positive and HPV-negative tumors are compared discussing clinicopathological factors, prognosis, outcome following treatment, and the molecular and genetic differences. Currently, the standard of care for oropharyngeal cancer is both surgery and post-operative radiotherapy with or without cisplatin or concurrent chemo-radiotherapy. The latter is used more often, especially in cancers of tonsil and base of tongue. However, there is increased interest in trying to de-intensify treatment and in the development of new treatments to target the underlying different molecular pathways of HPV-positive cancers. The current clinical trials involving surgery, chemotherapy, and radiation therapy are discussed. The new targeted treatments are also summarized. Although there is currently is no evidence from prospective studies to support a change in the treatment algorithm, the treatment options for patients with HPV-positive disease are likely to change in the future. Springer Healthcare 2015-09-09 2015 /pmc/articles/PMC4837939/ /pubmed/27182480 http://dx.doi.org/10.1007/s40487-015-0008-5 Text en © Springer Healthcare 2015 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Hay, Ashley
Ganly, Ian
Targeted Therapy in Oropharyngeal Squamous Cell Carcinoma: The Implications of HPV for Therapy
title Targeted Therapy in Oropharyngeal Squamous Cell Carcinoma: The Implications of HPV for Therapy
title_full Targeted Therapy in Oropharyngeal Squamous Cell Carcinoma: The Implications of HPV for Therapy
title_fullStr Targeted Therapy in Oropharyngeal Squamous Cell Carcinoma: The Implications of HPV for Therapy
title_full_unstemmed Targeted Therapy in Oropharyngeal Squamous Cell Carcinoma: The Implications of HPV for Therapy
title_short Targeted Therapy in Oropharyngeal Squamous Cell Carcinoma: The Implications of HPV for Therapy
title_sort targeted therapy in oropharyngeal squamous cell carcinoma: the implications of hpv for therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837939/
https://www.ncbi.nlm.nih.gov/pubmed/27182480
http://dx.doi.org/10.1007/s40487-015-0008-5
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