Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity

A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on al...

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Detalles Bibliográficos
Autores principales: Toma, Vlad Al., Farcaș, Anca D., Roman, Ioana, Sevastre, Bogdan, Hathazi, Denisa, Scurtu, Florina, Damian, Grigore, Silaghi-Dumitrescu, Radu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838227/
https://www.ncbi.nlm.nih.gov/pubmed/27097326
http://dx.doi.org/10.1371/journal.pone.0153909
Descripción
Sumario:A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on albumin as well as based on rubrerythrin appear to offer observable physiological advantages.

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