Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity

A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on al...

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Autores principales: Toma, Vlad Al., Farcaș, Anca D., Roman, Ioana, Sevastre, Bogdan, Hathazi, Denisa, Scurtu, Florina, Damian, Grigore, Silaghi-Dumitrescu, Radu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838227/
https://www.ncbi.nlm.nih.gov/pubmed/27097326
http://dx.doi.org/10.1371/journal.pone.0153909
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author Toma, Vlad Al.
Farcaș, Anca D.
Roman, Ioana
Sevastre, Bogdan
Hathazi, Denisa
Scurtu, Florina
Damian, Grigore
Silaghi-Dumitrescu, Radu
author_facet Toma, Vlad Al.
Farcaș, Anca D.
Roman, Ioana
Sevastre, Bogdan
Hathazi, Denisa
Scurtu, Florina
Damian, Grigore
Silaghi-Dumitrescu, Radu
author_sort Toma, Vlad Al.
collection PubMed
description A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on albumin as well as based on rubrerythrin appear to offer observable physiological advantages.
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spelling pubmed-48382272016-04-29 Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity Toma, Vlad Al. Farcaș, Anca D. Roman, Ioana Sevastre, Bogdan Hathazi, Denisa Scurtu, Florina Damian, Grigore Silaghi-Dumitrescu, Radu PLoS One Research Article A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on albumin as well as based on rubrerythrin appear to offer observable physiological advantages. Public Library of Science 2016-04-20 /pmc/articles/PMC4838227/ /pubmed/27097326 http://dx.doi.org/10.1371/journal.pone.0153909 Text en © 2016 Toma et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Toma, Vlad Al.
Farcaș, Anca D.
Roman, Ioana
Sevastre, Bogdan
Hathazi, Denisa
Scurtu, Florina
Damian, Grigore
Silaghi-Dumitrescu, Radu
Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity
title Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity
title_full Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity
title_fullStr Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity
title_full_unstemmed Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity
title_short Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity
title_sort comparative in vivo effects of hemoglobin-based oxygen carriers (hboc) with varying prooxidant and physiological reactivity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838227/
https://www.ncbi.nlm.nih.gov/pubmed/27097326
http://dx.doi.org/10.1371/journal.pone.0153909
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