Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation

TDP-43 is a protein that forms aggregates implicated in amyotrophic lateral sclerosis. In response to a recent study, this Formal Comment argues that the pH-dependent solubility of this protein is better explained by the mutual repulsion of charged groups than by the formation of hydrogen bonds.

Detalles Bibliográficos
Autores principales: Mompeán, Miguel, Chakrabartty, Avijit, Buratti, Emanuele, Laurents, Douglas V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Formal Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838238/
https://www.ncbi.nlm.nih.gov/pubmed/27096426
http://dx.doi.org/10.1371/journal.pbio.1002447
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author Mompeán, Miguel
Chakrabartty, Avijit
Buratti, Emanuele
Laurents, Douglas V.
author_facet Mompeán, Miguel
Chakrabartty, Avijit
Buratti, Emanuele
Laurents, Douglas V.
author_sort Mompeán, Miguel
collection PubMed
description TDP-43 is a protein that forms aggregates implicated in amyotrophic lateral sclerosis. In response to a recent study, this Formal Comment argues that the pH-dependent solubility of this protein is better explained by the mutual repulsion of charged groups than by the formation of hydrogen bonds.
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spelling pubmed-48382382016-04-29 Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation Mompeán, Miguel Chakrabartty, Avijit Buratti, Emanuele Laurents, Douglas V. PLoS Biol Formal Comment TDP-43 is a protein that forms aggregates implicated in amyotrophic lateral sclerosis. In response to a recent study, this Formal Comment argues that the pH-dependent solubility of this protein is better explained by the mutual repulsion of charged groups than by the formation of hydrogen bonds. Public Library of Science 2016-04-20 /pmc/articles/PMC4838238/ /pubmed/27096426 http://dx.doi.org/10.1371/journal.pbio.1002447 Text en © 2016 Mompeán et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Formal Comment
Mompeán, Miguel
Chakrabartty, Avijit
Buratti, Emanuele
Laurents, Douglas V.
Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation
title Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation
title_full Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation
title_fullStr Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation
title_full_unstemmed Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation
title_short Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation
title_sort electrostatic repulsion governs tdp-43 c-terminal domain aggregation
topic Formal Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838238/
https://www.ncbi.nlm.nih.gov/pubmed/27096426
http://dx.doi.org/10.1371/journal.pbio.1002447
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AT chakrabarttyavijit electrostaticrepulsiongovernstdp43cterminaldomainaggregation
AT burattiemanuele electrostaticrepulsiongovernstdp43cterminaldomainaggregation
AT laurentsdouglasv electrostaticrepulsiongovernstdp43cterminaldomainaggregation

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