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Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation
TDP-43 is a protein that forms aggregates implicated in amyotrophic lateral sclerosis. In response to a recent study, this Formal Comment argues that the pH-dependent solubility of this protein is better explained by the mutual repulsion of charged groups than by the formation of hydrogen bonds.
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838238/ https://www.ncbi.nlm.nih.gov/pubmed/27096426 http://dx.doi.org/10.1371/journal.pbio.1002447 |