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Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses

A major determinant in the change of the avian influenza virus host range to humans is the E627K substitution in the PB2 polymerase protein. However, the polymerase activity of avian influenza viruses with a single PB2-E627K mutation is still lower than that of seasonal human influenza viruses, impl...

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Detalles Bibliográficos
Autores principales:	Arai, Yasuha, Kawashita, Norihito, Daidoji, Tomo, Ibrahim, Madiha S., El-Gendy, Emad M., Takagi, Tatsuya, Takahashi, Kazuo, Suzuki, Yasuo, Ikuta, Kazuyoshi, Nakaya, Takaaki, Shioda, Tatsuo, Watanabe, Yohei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838241/ https://www.ncbi.nlm.nih.gov/pubmed/27097026 http://dx.doi.org/10.1371/journal.ppat.1005583

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