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The Role of the Insular Cortex in Retaliation

The insular cortex has consistently been associated with various aspects of emotion regulation and social interaction, including anger processing and overt aggression. Aggression research distinguishes proactive or instrumental aggression from retaliation, i.e. aggression in response to provocation....

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Autores principales: Emmerling, Franziska, Schuhmann, Teresa, Lobbestael, Jill, Arntz, Arnoud, Brugman, Suzanne, Sack, Alexander Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838249/
https://www.ncbi.nlm.nih.gov/pubmed/27096431
http://dx.doi.org/10.1371/journal.pone.0152000
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author Emmerling, Franziska
Schuhmann, Teresa
Lobbestael, Jill
Arntz, Arnoud
Brugman, Suzanne
Sack, Alexander Thomas
author_facet Emmerling, Franziska
Schuhmann, Teresa
Lobbestael, Jill
Arntz, Arnoud
Brugman, Suzanne
Sack, Alexander Thomas
author_sort Emmerling, Franziska
collection PubMed
description The insular cortex has consistently been associated with various aspects of emotion regulation and social interaction, including anger processing and overt aggression. Aggression research distinguishes proactive or instrumental aggression from retaliation, i.e. aggression in response to provocation. Here, we investigated the specific role of the insular cortex during retaliation, employing a controlled behavioral aggression paradigm implementing different levels of provocation. Fifteen healthy male volunteers underwent whole brain functional magnetic resonance imaging (fMRI) to identify brain regions involved in interaction with either a provoking or a non-provoking opponent. FMRI group analyses were complemented by examining the parametric modulations of brain activity related to the individual level of displayed aggression. These analyses identified a hemispheric lateralization as well as an anatomical segregation of insular cortex with specifically the left posterior part being involved in retaliation. The left-lateralization of insular activity during retaliation is in accordance with evidence from electro-physiological studies, suggesting left-lateralized fronto-cortical dominance during anger processing and aggressive acts. The posterior localization of insular activity, on the other hand, suggests a spatial segregation within insular cortex with particularly the posterior part being involved in the processing of emotions that trigger intense bodily sensations and immediate action tendencies.
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spelling pubmed-48382492016-04-29 The Role of the Insular Cortex in Retaliation Emmerling, Franziska Schuhmann, Teresa Lobbestael, Jill Arntz, Arnoud Brugman, Suzanne Sack, Alexander Thomas PLoS One Research Article The insular cortex has consistently been associated with various aspects of emotion regulation and social interaction, including anger processing and overt aggression. Aggression research distinguishes proactive or instrumental aggression from retaliation, i.e. aggression in response to provocation. Here, we investigated the specific role of the insular cortex during retaliation, employing a controlled behavioral aggression paradigm implementing different levels of provocation. Fifteen healthy male volunteers underwent whole brain functional magnetic resonance imaging (fMRI) to identify brain regions involved in interaction with either a provoking or a non-provoking opponent. FMRI group analyses were complemented by examining the parametric modulations of brain activity related to the individual level of displayed aggression. These analyses identified a hemispheric lateralization as well as an anatomical segregation of insular cortex with specifically the left posterior part being involved in retaliation. The left-lateralization of insular activity during retaliation is in accordance with evidence from electro-physiological studies, suggesting left-lateralized fronto-cortical dominance during anger processing and aggressive acts. The posterior localization of insular activity, on the other hand, suggests a spatial segregation within insular cortex with particularly the posterior part being involved in the processing of emotions that trigger intense bodily sensations and immediate action tendencies. Public Library of Science 2016-04-20 /pmc/articles/PMC4838249/ /pubmed/27096431 http://dx.doi.org/10.1371/journal.pone.0152000 Text en © 2016 Emmerling et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Emmerling, Franziska
Schuhmann, Teresa
Lobbestael, Jill
Arntz, Arnoud
Brugman, Suzanne
Sack, Alexander Thomas
The Role of the Insular Cortex in Retaliation
title The Role of the Insular Cortex in Retaliation
title_full The Role of the Insular Cortex in Retaliation
title_fullStr The Role of the Insular Cortex in Retaliation
title_full_unstemmed The Role of the Insular Cortex in Retaliation
title_short The Role of the Insular Cortex in Retaliation
title_sort role of the insular cortex in retaliation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838249/
https://www.ncbi.nlm.nih.gov/pubmed/27096431
http://dx.doi.org/10.1371/journal.pone.0152000
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