A commentary on the utility of a new L-DOPA-responsive dystonia mouse model

In a recent issue of Brain, we reported on the generation and characterization of a mouse model of the rare disease L-DOPA-responsive dystonia (DRD). Here, we discuss the utility of these mice for understanding broader disease processes and treatment strategies. Using specific experimental designs t...

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Detalles Bibliográficos
Autores principales: Rose, Samuel J., Hess, Ellen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838313/
https://www.ncbi.nlm.nih.gov/pubmed/27141408
http://dx.doi.org/10.1080/21675511.2015.1128617
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author Rose, Samuel J.
Hess, Ellen J.
author_facet Rose, Samuel J.
Hess, Ellen J.
author_sort Rose, Samuel J.
collection PubMed
description In a recent issue of Brain, we reported on the generation and characterization of a mouse model of the rare disease L-DOPA-responsive dystonia (DRD). Here, we discuss the utility of these mice for understanding broader disease processes and treatment strategies. Using specific experimental designs that either work “forward” from genetic etiology or “backward” from the symptomatic presentation, we discuss how our data and future work can be used to understand broader themes.
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spelling pubmed-48383132016-05-02 A commentary on the utility of a new L-DOPA-responsive dystonia mouse model Rose, Samuel J. Hess, Ellen J. Rare Dis Addendum In a recent issue of Brain, we reported on the generation and characterization of a mouse model of the rare disease L-DOPA-responsive dystonia (DRD). Here, we discuss the utility of these mice for understanding broader disease processes and treatment strategies. Using specific experimental designs that either work “forward” from genetic etiology or “backward” from the symptomatic presentation, we discuss how our data and future work can be used to understand broader themes. Taylor & Francis 2015-12-29 /pmc/articles/PMC4838313/ /pubmed/27141408 http://dx.doi.org/10.1080/21675511.2015.1128617 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Addendum
Rose, Samuel J.
Hess, Ellen J.
A commentary on the utility of a new L-DOPA-responsive dystonia mouse model
title A commentary on the utility of a new L-DOPA-responsive dystonia mouse model
title_full A commentary on the utility of a new L-DOPA-responsive dystonia mouse model
title_fullStr A commentary on the utility of a new L-DOPA-responsive dystonia mouse model
title_full_unstemmed A commentary on the utility of a new L-DOPA-responsive dystonia mouse model
title_short A commentary on the utility of a new L-DOPA-responsive dystonia mouse model
title_sort commentary on the utility of a new l-dopa-responsive dystonia mouse model
topic Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838313/
https://www.ncbi.nlm.nih.gov/pubmed/27141408
http://dx.doi.org/10.1080/21675511.2015.1128617
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