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p53 coordinates base excision repair to prevent genomic instability

DNA constantly undergoes chemical modification due to endogenous and exogenous mutagens. The DNA base excision repair (BER) pathway is the frontline mechanism handling the majority of these lesions, and primarily involves a DNA incision and subsequent resealing step. It is imperative that these proc...

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Detalles Bibliográficos
Autores principales:	Poletto, Mattia, Legrand, Arnaud J., Fletcher, Sally C., Dianov, Grigory L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838360/ https://www.ncbi.nlm.nih.gov/pubmed/26773055 http://dx.doi.org/10.1093/nar/gkw015

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