Quantitative sampling of conformational heterogeneity of a DNA hairpin using molecular dynamics simulations and ultrafast fluorescence spectroscopy

Molecular dynamics (MD) simulations and time resolved fluorescence (TRF) spectroscopy were combined to quantitatively describe the conformational landscape of the DNA primary binding sequence (PBS) of the HIV-1 genome, a short hairpin targeted by retroviral nucleocapsid proteins implicated in the vi...

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Detalles Bibliográficos
Autores principales: Voltz, Karine, Léonard, Jérémie, Touceda, Patricia Tourón, Conyard, Jamie, Chaker, Ziyad, Dejaegere, Annick, Godet, Julien, Mély, Yves, Haacke, Stefan, Stote, Roland H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838372/
https://www.ncbi.nlm.nih.gov/pubmed/26896800
http://dx.doi.org/10.1093/nar/gkw077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838372/
https://www.ncbi.nlm.nih.gov/pubmed/26896800
http://dx.doi.org/10.1093/nar/gkw077

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