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The crystal structure of human GlnRS provides basis for the development of neurological disorders
Cytosolic glutaminyl-tRNA synthetase (GlnRS) is the singular enzyme responsible for translation of glutamine codons. Compound heterozygous mutations in GlnRS cause severe brain disorders by a poorly understood mechanism. Herein, we present crystal structures of the wild type and two pathological mut...
Autores principales: | Ognjenović, Jana, Wu, Jiang, Matthies, Doreen, Baxa, Ulrich, Subramaniam, Sriram, Ling, Jiqiang, Simonović, Miljan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838373/ https://www.ncbi.nlm.nih.gov/pubmed/26869582 http://dx.doi.org/10.1093/nar/gkw082 |
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