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Structural basis for PHD(V)C5HCH(NSD1)–C2HR(Nizp1) interaction: implications for Sotos syndrome

Sotos syndrome is an overgrowth syndrome caused by mutations within the functional domains of NSD1 gene coding for NSD1, a multidomain protein regulating chromatin structure and gene expression. In particular, PHD(V)C5HCH(NSD1) tandem domain, composed by a classical (PHD(V)) and an atypical (C5HCH)...

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Detalles Bibliográficos
Autores principales:	Berardi, Andrea, Quilici, Giacomo, Spiliotopoulos, Dimitrios, Corral-Rodriguez, Maria Angeles, Martin-Garcia, Fernando, Degano, Massimo, Tonon, Giovanni, Ghitti, Michela, Musco, Giovanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838375/ https://www.ncbi.nlm.nih.gov/pubmed/26896805 http://dx.doi.org/10.1093/nar/gkw103

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