Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation

The lack of a surrogate-of-immunity assay presents a major barrier to Streptococcus pyogenes research. Modification of the Lancefield assay to include an antibody digestion step reduced inter-donor variation and permitted detection of the anti-streptococcal activity of intravenous immunoglobulin and...

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Autores principales: Reglinski, Mark, Lynskey, Nicola N., Sriskandan, Shiranee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Biomedical 2016
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838658/
https://www.ncbi.nlm.nih.gov/pubmed/27030640
http://dx.doi.org/10.1016/j.mimet.2016.03.015
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author Reglinski, Mark
Lynskey, Nicola N.
Sriskandan, Shiranee
author_facet Reglinski, Mark
Lynskey, Nicola N.
Sriskandan, Shiranee
author_sort Reglinski, Mark
collection PubMed
description The lack of a surrogate-of-immunity assay presents a major barrier to Streptococcus pyogenes research. Modification of the Lancefield assay to include an antibody digestion step reduced inter-donor variation and permitted detection of the anti-streptococcal activity of intravenous immunoglobulin and convalescent serum, thus facilitating retrospective evaluation of immunity using stored samples.
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spelling pubmed-48386582016-05-02 Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation Reglinski, Mark Lynskey, Nicola N. Sriskandan, Shiranee J Microbiol Methods Note The lack of a surrogate-of-immunity assay presents a major barrier to Streptococcus pyogenes research. Modification of the Lancefield assay to include an antibody digestion step reduced inter-donor variation and permitted detection of the anti-streptococcal activity of intravenous immunoglobulin and convalescent serum, thus facilitating retrospective evaluation of immunity using stored samples. Elsevier Biomedical 2016-05 /pmc/articles/PMC4838658/ /pubmed/27030640 http://dx.doi.org/10.1016/j.mimet.2016.03.015 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Note
Reglinski, Mark
Lynskey, Nicola N.
Sriskandan, Shiranee
Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation
title Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation
title_full Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation
title_fullStr Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation
title_full_unstemmed Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation
title_short Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation
title_sort modification of the classical lancefield assay of group a streptococcal killing to reduce inter-donor variation
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838658/
https://www.ncbi.nlm.nih.gov/pubmed/27030640
http://dx.doi.org/10.1016/j.mimet.2016.03.015
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