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Mitochondrial dysfunction associated with glucocerebrosidase deficiency

The lysosomal hydrolase glucocerebrosidase (GCase) is encoded for by the GBA gene. Homozygous GBA mutations cause Gaucher disease (GD), a lysosomal storage disorder. Furthermore, homozygous and heterozygous GBA mutations are numerically the greatest genetic risk factor for developing Parkinson'...

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Detalles Bibliográficos
Autores principales:	Gegg, Matthew E., Schapira, Anthony H.V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838669/ https://www.ncbi.nlm.nih.gov/pubmed/26388395 http://dx.doi.org/10.1016/j.nbd.2015.09.006

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