Investigating the Implications of a Variable RBE on Proton Dose Fractionation Across a Clinical Pencil Beam Scanned Spread-Out Bragg Peak

PURPOSE: To investigate the clinical implications of a variable relative biological effectiveness (RBE) on proton dose fractionation. Using acute exposures, the current clinical adoption of a generic, constant cell killing RBE has been shown to underestimate the effect of the sharp increase in linea...

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Detalles Bibliográficos
Autores principales: Marshall, Thomas I., Chaudhary, Pankaj, Michaelidesová, Anna, Vachelová, Jana, Davídková, Marie, Vondráček, Vladimir, Schettino, Giuseppe, Prise, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Inc 2016
Materias:
RBE and Particle Therapy Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838672/
https://www.ncbi.nlm.nih.gov/pubmed/27084630
http://dx.doi.org/10.1016/j.ijrobp.2016.02.029

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