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Sex differences in aneurysm morphologies and clinical outcomes in ruptured anterior communicating artery aneurysms: a retrospective study

OBJECTIVES: Ruptured anterior communicating artery (ACoA) aneurysms occur more frequently in men. The purpose of the study was to investigate sex difference in aneurysm morphologies and clinical outcomes in patients with ruptured ACoA aneurysms. SETTING: A tertiary referral hospital. PARTICIPANTS: A...

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Autores principales: Lin, Boli, Chen, Weijian, Ruan, Lei, Chen, Yongchun, Zhong, Ming, Zhuge, Qichuan, Fan, Liang Hao, Zhao, Bing, Yang, Yunjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838700/
https://www.ncbi.nlm.nih.gov/pubmed/27084272
http://dx.doi.org/10.1136/bmjopen-2015-009920
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author Lin, Boli
Chen, Weijian
Ruan, Lei
Chen, Yongchun
Zhong, Ming
Zhuge, Qichuan
Fan, Liang Hao
Zhao, Bing
Yang, Yunjun
author_facet Lin, Boli
Chen, Weijian
Ruan, Lei
Chen, Yongchun
Zhong, Ming
Zhuge, Qichuan
Fan, Liang Hao
Zhao, Bing
Yang, Yunjun
author_sort Lin, Boli
collection PubMed
description OBJECTIVES: Ruptured anterior communicating artery (ACoA) aneurysms occur more frequently in men. The purpose of the study was to investigate sex difference in aneurysm morphologies and clinical outcomes in patients with ruptured ACoA aneurysms. SETTING: A tertiary referral hospital. PARTICIPANTS: A total of 574 consecutive patients with ACoA aneurysms were admitted to our hospital from December 2007 to February 2015. In all, 474 patients (257 men and 217 women) with ruptured ACoA aneurysms were included in the study. MAIN OUTCOME MEASURES: Aneurysm morphologies were measured using computed tomographic angiography and clinical outcomes were measured with Glasgow coma score at discharge. RESULTS: The aneurysm sizes (p=0.001), aneurysm heights (p=0.011), size ratios (p<0.001), flow angles (p=0.047) and vessel angles (p=0.046) were larger in the male patients than in the females. The female patients more often had larger vessel sizes (p=0.002). Multivariate logistic analysis revealed that significant differences in aneurysm morphologies between men and women were aneurysm size (OR 1.1, 95% CI 1.0 to 1.3; p=0.036), aneurysm height (OR 0.8, 95% CI 0. to 0.9; p=0.006) and size ratio (OR 1.4, 95% CI 0.5 to 1.7; p=0.001). There were no statistically significant differences in the outcomes between men and women (OR 1.0, 95% CI 0.6 to 1.7, p=0.857). CONCLUSIONS: The men were independently associated with larger aneurysm sizes, greater aneurysm heights and larger size ratios. Sex was not a risk factor for poor outcome in patients with ruptured ACoA aneurysms.
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spelling pubmed-48387002016-04-22 Sex differences in aneurysm morphologies and clinical outcomes in ruptured anterior communicating artery aneurysms: a retrospective study Lin, Boli Chen, Weijian Ruan, Lei Chen, Yongchun Zhong, Ming Zhuge, Qichuan Fan, Liang Hao Zhao, Bing Yang, Yunjun BMJ Open Surgery OBJECTIVES: Ruptured anterior communicating artery (ACoA) aneurysms occur more frequently in men. The purpose of the study was to investigate sex difference in aneurysm morphologies and clinical outcomes in patients with ruptured ACoA aneurysms. SETTING: A tertiary referral hospital. PARTICIPANTS: A total of 574 consecutive patients with ACoA aneurysms were admitted to our hospital from December 2007 to February 2015. In all, 474 patients (257 men and 217 women) with ruptured ACoA aneurysms were included in the study. MAIN OUTCOME MEASURES: Aneurysm morphologies were measured using computed tomographic angiography and clinical outcomes were measured with Glasgow coma score at discharge. RESULTS: The aneurysm sizes (p=0.001), aneurysm heights (p=0.011), size ratios (p<0.001), flow angles (p=0.047) and vessel angles (p=0.046) were larger in the male patients than in the females. The female patients more often had larger vessel sizes (p=0.002). Multivariate logistic analysis revealed that significant differences in aneurysm morphologies between men and women were aneurysm size (OR 1.1, 95% CI 1.0 to 1.3; p=0.036), aneurysm height (OR 0.8, 95% CI 0. to 0.9; p=0.006) and size ratio (OR 1.4, 95% CI 0.5 to 1.7; p=0.001). There were no statistically significant differences in the outcomes between men and women (OR 1.0, 95% CI 0.6 to 1.7, p=0.857). CONCLUSIONS: The men were independently associated with larger aneurysm sizes, greater aneurysm heights and larger size ratios. Sex was not a risk factor for poor outcome in patients with ruptured ACoA aneurysms. BMJ Publishing Group 2016-04-15 /pmc/articles/PMC4838700/ /pubmed/27084272 http://dx.doi.org/10.1136/bmjopen-2015-009920 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Surgery
Lin, Boli
Chen, Weijian
Ruan, Lei
Chen, Yongchun
Zhong, Ming
Zhuge, Qichuan
Fan, Liang Hao
Zhao, Bing
Yang, Yunjun
Sex differences in aneurysm morphologies and clinical outcomes in ruptured anterior communicating artery aneurysms: a retrospective study
title Sex differences in aneurysm morphologies and clinical outcomes in ruptured anterior communicating artery aneurysms: a retrospective study
title_full Sex differences in aneurysm morphologies and clinical outcomes in ruptured anterior communicating artery aneurysms: a retrospective study
title_fullStr Sex differences in aneurysm morphologies and clinical outcomes in ruptured anterior communicating artery aneurysms: a retrospective study
title_full_unstemmed Sex differences in aneurysm morphologies and clinical outcomes in ruptured anterior communicating artery aneurysms: a retrospective study
title_short Sex differences in aneurysm morphologies and clinical outcomes in ruptured anterior communicating artery aneurysms: a retrospective study
title_sort sex differences in aneurysm morphologies and clinical outcomes in ruptured anterior communicating artery aneurysms: a retrospective study
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838700/
https://www.ncbi.nlm.nih.gov/pubmed/27084272
http://dx.doi.org/10.1136/bmjopen-2015-009920
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