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Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients

OBJECTIVE: To examine the associations between CD4 recovery, dyslipidaemia and apolipoprotein (APO) gene single nucleotide polymorphisms (SNPs) following highly active antiretroviral therapy (HAART). DESIGN: Retrospective observational cohort study. SETTING: A major HIV care clinic in Hong Kong. PAR...

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Autores principales: Chan, Denise Pui-Chung, Lee, Man-Po, Wong, Ngai-Sze, Leung, Ross Ka-Kit, Naftalin, Claire Melinda, Lee, Shui-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838726/
https://www.ncbi.nlm.nih.gov/pubmed/27067897
http://dx.doi.org/10.1136/bmjopen-2015-010998
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author Chan, Denise Pui-Chung
Lee, Man-Po
Wong, Ngai-Sze
Leung, Ross Ka-Kit
Naftalin, Claire Melinda
Lee, Shui-Shan
author_facet Chan, Denise Pui-Chung
Lee, Man-Po
Wong, Ngai-Sze
Leung, Ross Ka-Kit
Naftalin, Claire Melinda
Lee, Shui-Shan
author_sort Chan, Denise Pui-Chung
collection PubMed
description OBJECTIVE: To examine the associations between CD4 recovery, dyslipidaemia and apolipoprotein (APO) gene single nucleotide polymorphisms (SNPs) following highly active antiretroviral therapy (HAART). DESIGN: Retrospective observational cohort study. SETTING: A major HIV care clinic in Hong Kong. PARTICIPANTS: 197 Chinese treatment-naïve HIV patients. OUTCOME MEASURES: Maximum CD4 count and its rise 2–3 years after HAART initiation and their association with abnormal total cholesterol (TC), triglyceride (TG) and 8 selected APO SNP at multiple time points. RESULTS: Before HAART, abnormal levels of TC, TG, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were detected in 13%, 26%, 59% and 19% of the recruited patients, respectively. APOA5 −1131T>C and c.553G>T were significantly associated with high pre-HAART TG while APOE 2198C>T was correlated with high TG at baseline and/or a rise 2–3 years following HAART initiation. Poor CD4 achievement, defined as the highest CD4 count <350/μL and a net gain of <100/μL, was associated with a low CD4 count ≤200/μL at baseline and a rise of TC beyond 5.17 mmol/L following HAART with or without the use of antilipid agents. Conversely, satisfactory CD4 achievement was associated with APOC3 3238GG genotype. Applying a linear generalised estimating equation, APOA5 −1131T>C was shown to be a predictor of a weaker temporal trend for CD4 response in the presence of a low baseline CD4≤200/μL. CONCLUSIONS: Dyslipidaemia plays a predictive role in impacting immunological recovery following HAART, which could be partly explained by the APO gene SNP.
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spelling pubmed-48387262016-04-22 Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients Chan, Denise Pui-Chung Lee, Man-Po Wong, Ngai-Sze Leung, Ross Ka-Kit Naftalin, Claire Melinda Lee, Shui-Shan BMJ Open HIV/AIDS OBJECTIVE: To examine the associations between CD4 recovery, dyslipidaemia and apolipoprotein (APO) gene single nucleotide polymorphisms (SNPs) following highly active antiretroviral therapy (HAART). DESIGN: Retrospective observational cohort study. SETTING: A major HIV care clinic in Hong Kong. PARTICIPANTS: 197 Chinese treatment-naïve HIV patients. OUTCOME MEASURES: Maximum CD4 count and its rise 2–3 years after HAART initiation and their association with abnormal total cholesterol (TC), triglyceride (TG) and 8 selected APO SNP at multiple time points. RESULTS: Before HAART, abnormal levels of TC, TG, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were detected in 13%, 26%, 59% and 19% of the recruited patients, respectively. APOA5 −1131T>C and c.553G>T were significantly associated with high pre-HAART TG while APOE 2198C>T was correlated with high TG at baseline and/or a rise 2–3 years following HAART initiation. Poor CD4 achievement, defined as the highest CD4 count <350/μL and a net gain of <100/μL, was associated with a low CD4 count ≤200/μL at baseline and a rise of TC beyond 5.17 mmol/L following HAART with or without the use of antilipid agents. Conversely, satisfactory CD4 achievement was associated with APOC3 3238GG genotype. Applying a linear generalised estimating equation, APOA5 −1131T>C was shown to be a predictor of a weaker temporal trend for CD4 response in the presence of a low baseline CD4≤200/μL. CONCLUSIONS: Dyslipidaemia plays a predictive role in impacting immunological recovery following HAART, which could be partly explained by the APO gene SNP. BMJ Publishing Group 2016-04-11 /pmc/articles/PMC4838726/ /pubmed/27067897 http://dx.doi.org/10.1136/bmjopen-2015-010998 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle HIV/AIDS
Chan, Denise Pui-Chung
Lee, Man-Po
Wong, Ngai-Sze
Leung, Ross Ka-Kit
Naftalin, Claire Melinda
Lee, Shui-Shan
Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients
title Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients
title_full Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients
title_fullStr Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients
title_full_unstemmed Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients
title_short Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients
title_sort association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of chinese hiv patients
topic HIV/AIDS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838726/
https://www.ncbi.nlm.nih.gov/pubmed/27067897
http://dx.doi.org/10.1136/bmjopen-2015-010998
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