Effect of Yi Gong San Decoction on Iron Homeostasis in a Mouse Model of Acute Inflammation

We investigated the effect of Yi Gong San (YGS) decoction on iron homeostasis and the possible underlying mechanisms in a mouse model of acute inflammation in this study. Our findings suggest that YGS regulates iron homeostasis by downregulating the level of HAMP mRNA, which may depend on regulation...

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Detalles Bibliográficos
Autores principales: Zheng, Qin, Guan, Yu, Xia, Lemin, Wang, Zhicheng, Jiang, Yiling, Zhang, Xiaofeng, Wang, Jianying, Wang, Guohua, Pu, Yiqiong, Xia, Jing, Luo, Meihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838806/
https://www.ncbi.nlm.nih.gov/pubmed/27143982
http://dx.doi.org/10.1155/2016/2696480
Descripción
Sumario:We investigated the effect of Yi Gong San (YGS) decoction on iron homeostasis and the possible underlying mechanisms in a mouse model of acute inflammation in this study. Our findings suggest that YGS regulates iron homeostasis by downregulating the level of HAMP mRNA, which may depend on regulation of the IL-6/STAT3 or BMP/HJV/SMAD pathway during acute inflammation.

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