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Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography

Lens-free digital in-line holography (LDIH) is a promising technology for portable, wide field-of-view imaging. Its resolution, however, is limited by the inherent pixel size of an imaging device. Here we present a new computational approach to achieve sub-pixel resolution for LDIH. The developed me...

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Detalles Bibliográficos
Autores principales: Song, Jun, Leon Swisher, Christine, Im, Hyungsoon, Jeong, Sangmoo, Pathania, Divya, Iwamoto, Yoshiko, Pivovarov, Misha, Weissleder, Ralph, Lee, Hakho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838824/
https://www.ncbi.nlm.nih.gov/pubmed/27098438
http://dx.doi.org/10.1038/srep24681
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author Song, Jun
Leon Swisher, Christine
Im, Hyungsoon
Jeong, Sangmoo
Pathania, Divya
Iwamoto, Yoshiko
Pivovarov, Misha
Weissleder, Ralph
Lee, Hakho
author_facet Song, Jun
Leon Swisher, Christine
Im, Hyungsoon
Jeong, Sangmoo
Pathania, Divya
Iwamoto, Yoshiko
Pivovarov, Misha
Weissleder, Ralph
Lee, Hakho
author_sort Song, Jun
collection PubMed
description Lens-free digital in-line holography (LDIH) is a promising technology for portable, wide field-of-view imaging. Its resolution, however, is limited by the inherent pixel size of an imaging device. Here we present a new computational approach to achieve sub-pixel resolution for LDIH. The developed method is a sparsity-based reconstruction with the capability to handle the non-linear nature of LDIH. We systematically characterized the algorithm through simulation and LDIH imaging studies. The method achieved the spatial resolution down to one-third of the pixel size, while requiring only single-frame imaging without any hardware modifications. This new approach can be used as a general framework to enhance the resolution in nonlinear holographic systems.
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spelling pubmed-48388242016-04-27 Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography Song, Jun Leon Swisher, Christine Im, Hyungsoon Jeong, Sangmoo Pathania, Divya Iwamoto, Yoshiko Pivovarov, Misha Weissleder, Ralph Lee, Hakho Sci Rep Article Lens-free digital in-line holography (LDIH) is a promising technology for portable, wide field-of-view imaging. Its resolution, however, is limited by the inherent pixel size of an imaging device. Here we present a new computational approach to achieve sub-pixel resolution for LDIH. The developed method is a sparsity-based reconstruction with the capability to handle the non-linear nature of LDIH. We systematically characterized the algorithm through simulation and LDIH imaging studies. The method achieved the spatial resolution down to one-third of the pixel size, while requiring only single-frame imaging without any hardware modifications. This new approach can be used as a general framework to enhance the resolution in nonlinear holographic systems. Nature Publishing Group 2016-04-21 /pmc/articles/PMC4838824/ /pubmed/27098438 http://dx.doi.org/10.1038/srep24681 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Song, Jun
Leon Swisher, Christine
Im, Hyungsoon
Jeong, Sangmoo
Pathania, Divya
Iwamoto, Yoshiko
Pivovarov, Misha
Weissleder, Ralph
Lee, Hakho
Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography
title Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography
title_full Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography
title_fullStr Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography
title_full_unstemmed Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography
title_short Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography
title_sort sparsity-based pixel super resolution for lens-free digital in-line holography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838824/
https://www.ncbi.nlm.nih.gov/pubmed/27098438
http://dx.doi.org/10.1038/srep24681
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