Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

Despite the well-established role of the human serotonin transporter (hSERT) in the treatment of depression, the molecular details of antidepressant drug binding are still not fully understood. Here we utilize amber codon suppression in a membrane-bound transporter protein to encode photocrosslinkin...

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Detalles Bibliográficos
Autores principales: Rannversson, Hafsteinn, Andersen, Jacob, Sørensen, Lena, Bang-Andersen, Benny, Park, Minyoung, Huber, Thomas, Sakmar, Thomas P., Strømgaard, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838859/
https://www.ncbi.nlm.nih.gov/pubmed/27089947
http://dx.doi.org/10.1038/ncomms11261

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