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Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

Intracellular accumulation of tau protein is hallmark of sporadic Alzheimer’s disease (AD), however, the cellular mechanism whereby tau accumulation causes neurodegeneration is poorly understood. Here we report that overexpression of human wild-type full-length tau (termed htau) disrupted mitochondr...

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Detalles Bibliográficos
Autores principales:	Li, Xia-Chun, Hu, Yu, Wang, Zhi-hao, Luo, Yu, Zhang, Yao, Liu, Xiu-Ping, Feng, Qiong, Wang, Qun, Ye, Keqiang, Liu, Gong-Ping, Wang, Jian-Zhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838862/ https://www.ncbi.nlm.nih.gov/pubmed/27099072 http://dx.doi.org/10.1038/srep24756

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