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A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II

Dramatic global increases in future numbers of people with dementia have been predicted. No multicentre population-based study powered to detect changes over time has reported dementia incidence. MRC Cognitive Function and Ageing Study (CFAS) undertook baseline interviews in populations aged 65+ yea...

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Autores principales: Matthews, F. E., Stephan, B. C. M., Robinson, L., Jagger, C., Barnes, L. E., Arthur, A., Brayne, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838896/
https://www.ncbi.nlm.nih.gov/pubmed/27092707
http://dx.doi.org/10.1038/ncomms11398
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author Matthews, F. E.
Stephan, B. C. M.
Robinson, L.
Jagger, C.
Barnes, L. E.
Arthur, A.
Brayne, C.
author_facet Matthews, F. E.
Stephan, B. C. M.
Robinson, L.
Jagger, C.
Barnes, L. E.
Arthur, A.
Brayne, C.
author_sort Matthews, F. E.
collection PubMed
description Dramatic global increases in future numbers of people with dementia have been predicted. No multicentre population-based study powered to detect changes over time has reported dementia incidence. MRC Cognitive Function and Ageing Study (CFAS) undertook baseline interviews in populations aged 65+ years in England and Wales (1989–1994). Three areas (CFAS I) were selected for new sampling two decades later (2008–2011) with same geographical boundaries, sampling and approach methods (CFAS II). At 2 years CFAS I interviewed 5,156 (76% response) with 5,288 interviewed in CFAS II (74% response). Here we report a 20% drop in incidence (95% CI: 0–40%), driven by a reduction in men across all ages above 65. In the UK we estimate 209,600 new dementia cases per year. This study was uniquely designed to test for differences across geography and time. A reduction of age-specific incidence means that the numbers of people estimated to develop dementia in any year has remained relatively stable.
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spelling pubmed-48388962016-05-04 A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II Matthews, F. E. Stephan, B. C. M. Robinson, L. Jagger, C. Barnes, L. E. Arthur, A. Brayne, C. Nat Commun Article Dramatic global increases in future numbers of people with dementia have been predicted. No multicentre population-based study powered to detect changes over time has reported dementia incidence. MRC Cognitive Function and Ageing Study (CFAS) undertook baseline interviews in populations aged 65+ years in England and Wales (1989–1994). Three areas (CFAS I) were selected for new sampling two decades later (2008–2011) with same geographical boundaries, sampling and approach methods (CFAS II). At 2 years CFAS I interviewed 5,156 (76% response) with 5,288 interviewed in CFAS II (74% response). Here we report a 20% drop in incidence (95% CI: 0–40%), driven by a reduction in men across all ages above 65. In the UK we estimate 209,600 new dementia cases per year. This study was uniquely designed to test for differences across geography and time. A reduction of age-specific incidence means that the numbers of people estimated to develop dementia in any year has remained relatively stable. Nature Publishing Group 2016-04-19 /pmc/articles/PMC4838896/ /pubmed/27092707 http://dx.doi.org/10.1038/ncomms11398 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Matthews, F. E.
Stephan, B. C. M.
Robinson, L.
Jagger, C.
Barnes, L. E.
Arthur, A.
Brayne, C.
A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II
title A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II
title_full A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II
title_fullStr A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II
title_full_unstemmed A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II
title_short A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II
title_sort two decade dementia incidence comparison from the cognitive function and ageing studies i and ii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838896/
https://www.ncbi.nlm.nih.gov/pubmed/27092707
http://dx.doi.org/10.1038/ncomms11398
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