Optogenetic control of human neurons in organotypic brain cultures

Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-conc...

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Autores principales: Andersson, My, Avaliani, Natalia, Svensson, Andreas, Wickham, Jenny, Pinborg, Lars H., Jespersen, Bo, Christiansen, Søren H., Bengzon, Johan, Woldbye, David P.D., Kokaia, Merab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838935/
https://www.ncbi.nlm.nih.gov/pubmed/27098488
http://dx.doi.org/10.1038/srep24818
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author Andersson, My
Avaliani, Natalia
Svensson, Andreas
Wickham, Jenny
Pinborg, Lars H.
Jespersen, Bo
Christiansen, Søren H.
Bengzon, Johan
Woldbye, David P.D.
Kokaia, Merab
author_facet Andersson, My
Avaliani, Natalia
Svensson, Andreas
Wickham, Jenny
Pinborg, Lars H.
Jespersen, Bo
Christiansen, Søren H.
Bengzon, Johan
Woldbye, David P.D.
Kokaia, Merab
author_sort Andersson, My
collection PubMed
description Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.
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spelling pubmed-48389352016-04-28 Optogenetic control of human neurons in organotypic brain cultures Andersson, My Avaliani, Natalia Svensson, Andreas Wickham, Jenny Pinborg, Lars H. Jespersen, Bo Christiansen, Søren H. Bengzon, Johan Woldbye, David P.D. Kokaia, Merab Sci Rep Article Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies. Nature Publishing Group 2016-04-21 /pmc/articles/PMC4838935/ /pubmed/27098488 http://dx.doi.org/10.1038/srep24818 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Andersson, My
Avaliani, Natalia
Svensson, Andreas
Wickham, Jenny
Pinborg, Lars H.
Jespersen, Bo
Christiansen, Søren H.
Bengzon, Johan
Woldbye, David P.D.
Kokaia, Merab
Optogenetic control of human neurons in organotypic brain cultures
title Optogenetic control of human neurons in organotypic brain cultures
title_full Optogenetic control of human neurons in organotypic brain cultures
title_fullStr Optogenetic control of human neurons in organotypic brain cultures
title_full_unstemmed Optogenetic control of human neurons in organotypic brain cultures
title_short Optogenetic control of human neurons in organotypic brain cultures
title_sort optogenetic control of human neurons in organotypic brain cultures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838935/
https://www.ncbi.nlm.nih.gov/pubmed/27098488
http://dx.doi.org/10.1038/srep24818
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