Generation of a monoclonal antibody recognizing the CEACAM glycan structure and inhibiting adhesion using cancer tissue-originated spheroid as an antigen

Spheroids cultured directly from tumours can better reflect in vivo tumour characteristics than two-dimensional monolayer culture or three-dimensional culture of established cell lines. In this study, we generated antibodies by directly immunizing mice with primary-cultured living spheroids from hum...

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Detalles Bibliográficos
Autores principales: Sato, Yumi, Tateno, Hiroaki, Adachi, Jun, Okuyama, Hiroaki, Endo, Hiroko, Tomonaga, Takeshi, Inoue, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838943/
https://www.ncbi.nlm.nih.gov/pubmed/27098764
http://dx.doi.org/10.1038/srep24823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838943/
https://www.ncbi.nlm.nih.gov/pubmed/27098764
http://dx.doi.org/10.1038/srep24823

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