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Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells

BACKGROUND: Acquired resistance towards apoptosis is a hallmark of cancer. Elimination of cells bearing activated oncogenes or stimulation of tumor suppressor mediators may provide a selection pressure to overcome resistance. KC-53 is a novel biyouyanagin analogue known to elicit strong anti-inflamm...

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Detalles Bibliográficos
Autores principales:	Savva, Christiana G., Totokotsopoulos, Sotirios, Nicolaou, Kyriakos C., Neophytou, Christiana M., Constantinou, Andreas I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839067/ https://www.ncbi.nlm.nih.gov/pubmed/27098354 http://dx.doi.org/10.1186/s12885-016-2310-5

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