Fn14-Fc suppresses germinal center formation and pathogenic B cells in a lupus mouse model via inhibition of the TWEAK/Fn14 Pathway

BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune-mediated chronic inflammatory disease. Half of patients with SLE suffer from lupus nephritis, which is major cause of death in SLE. TNF-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) interactions med...

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Detalles Bibliográficos
Autores principales: Min, Hong-Ki, Kim, Sung-Min, Park, Jin-Sil, Byun, Jae-Kyeong, Lee, Jennifer, Kwok, Seung-Ki, Park, Young-Woo, Cho, Mi-La, Park, Sung-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839090/
https://www.ncbi.nlm.nih.gov/pubmed/27098560
http://dx.doi.org/10.1186/s12967-016-0846-4

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