Cargando…

Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance

Adipose tissue (AT) inflammation contributes to impaired insulin action, which is a major cause of type 2 diabetes. RBP4 is an adipocyte- and liver-derived protein with an important role in insulin resistance, metabolic syndrome, and AT inflammation. RBP4 elevation causes AT inflammation by activati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moraes-Vieira, Pedro M., Castoldi, Angela, Aryal, Pratik, Wellenstein, Kerry, Peroni, Odile D., Kahn, Barbara B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2016
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839203/ https://www.ncbi.nlm.nih.gov/pubmed/26936962 http://dx.doi.org/10.2337/db15-1696

Ejemplares similares

Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice
por: Zemany, Laura, et al.
Publicado: (2015)

B-Cell Cross-Presentation of Autologous Antigen Precipitates Diabetes
por: Mariño, Eliana, et al.
Publicado: (2012)

Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens
por: Dai, Yang D., et al.
Publicado: (2009)

Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes
por: Fourlanos, Spiros, et al.
Publicado: (2011)

Distinguishing Persistent Insulin Autoantibodies With Differential Risk: Nonradioactive Bivalent Proinsulin/Insulin Autoantibody Assay
por: Yu, Liping, et al.
Publicado: (2012)

Insulin Transactivator MafA Regulates Intrathymic Expression of Insulin and Affects Susceptibility to Type 1 Diabetes
por: Noso, Shinsuke, et al.
Publicado: (2010)

Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes
por: Bassi, Ênio J., et al.
Publicado: (2012)

Increased Effector Memory Insulin-Specific CD4(+) T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes
por: Spanier, Justin A., et al.
Publicado: (2017)

B-1a Lymphocytes Attenuate Insulin Resistance
por: Shen, Lei, et al.
Publicado: (2015)

Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes
por: Baker, Rocky L., et al.
Publicado: (2019)

The Core Cysteines, (C909) of Islet Antigen-2 and (C945) of Islet Antigen-2β, Are Crucial to Autoantibody Binding in Type 1 Diabetes
por: Elvers, Karen T., et al.
Publicado: (2013)

T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance
por: Zhong, Jixin, et al.
Publicado: (2014)

Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4(+) T Cells
por: Delong, Thomas, et al.
Publicado: (2011)

Soluble Antigen Arrays Efficiently Deliver Peptides and Arrest Spontaneous Autoimmune Diabetes
por: Firdessa-Fite, Rebuma, et al.
Publicado: (2021)

Virtual Optimization of Nasal Insulin Therapy Predicts Immunization Frequency to Be Crucial for Diabetes Protection
por: Fousteri, Georgia, et al.
Publicado: (2010)

Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01
por: Arribas-Layton, David, et al.
Publicado: (2020)

Preexisting Autoantibodies Predict Efficacy of Oral Insulin to Cure Autoimmune Diabetes in Combination With Anti-CD3
por: Mamchak, Alusha A., et al.
Publicado: (2012)

Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes
por: Thayer, Terri C., et al.
Publicado: (2011)

Mechanisms Underlying Antigen-Specific Tolerance of Stable and Convertible Th17 Cells During Suppression of Autoimmune Diabetes
por: Wan, Xiaoxiao, et al.
Publicado: (2012)

Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes
por: Liu, Yuk-Fun, et al.
Publicado: (2022)

Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice
por: Nakayama, Maki, et al.
Publicado: (2012)

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8(+) T Cells
por: Pearson, James A., et al.
Publicado: (2016)

Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models
por: McGuire, Helen M., et al.
Publicado: (2011)

RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women
por: Kilicarslan, Murat, et al.
Publicado: (2020)

Following the Fate of One Insulin-Reactive CD4 T cell: Conversion Into Teffs and Tregs in the Periphery Controls Diabetes in NOD Mice
por: Fousteri, Georgia, et al.
Publicado: (2012)

Interleukin-10(+) Regulatory B Cells Arise Within Antigen-Experienced CD40(+) B Cells to Maintain Tolerance to Islet Autoantigens
por: Kleffel, Sonja, et al.
Publicado: (2015)

Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes
por: Martin, Andrea P., et al.
Publicado: (2008)

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
por: Krishnamurthy, Balasubramanian, et al.
Publicado: (2012)

TLR2- and Dectin 1–Associated Innate Immune Response Modulates T-Cell Response to Pancreatic β-Cell Antigen and Prevents Type 1 Diabetes
por: Karumuthil-Melethil, Subha, et al.
Publicado: (2015)

Uncoupling of Proliferation and Cytokines From Suppression Within the CD4+CD25+Foxp3+ T–Cell Compartment in the 1st Year of Human Type 1 Diabetes
por: Hughson, Angela, et al.
Publicado: (2011)

Deficiency in B7-H1 (PD-L1)/PD-1 Coinhibition Triggers Pancreatic β-Cell Destruction by Insulin-Specific, Murine CD8 T-Cells
por: Rajasalu, Tarvo, et al.
Publicado: (2010)

Transforming Growth Factor-β Suppresses the Activation of CD8(+) T-Cells When Naïve but Promotes Their Survival and Function Once Antigen Experienced : A Two-Faced Impact on Autoimmunity
por: Filippi, Christophe M., et al.
Publicado: (2008)

A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis–Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes
por: Sassi, Gabriele, et al.
Publicado: (2023)

Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture
por: Allen, Jennifer S., et al.
Publicado: (2009)

Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizing Immunotherapy
por: Bertin-Maghit, Sebastien, et al.
Publicado: (2011)

HLA-B7–Restricted Islet Epitopes Are Differentially Recognized in Type 1 Diabetic Children and Adults and Form Weak Peptide-HLA Complexes
por: Scotto, Matthieu, et al.
Publicado: (2012)

An Unusual Presentation of Nocardiosis in an Allogeneic Transplant Recipient
por: Ibrahim, Uroosa, et al.
Publicado: (2016)

Zinc transporter 8 autoantibody testing requires age-related cut-offs
por: Grace, Sian Louise, et al.
Publicado: (2021)

Complement-dependent cytotoxicity and Luminex technology for human leucocyte antigen antibody detection in kidney transplant candidates exposed to different sensitizing events
por: Katalinić, Nataša, et al.
Publicado: (2017)

Immune Cell–Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin
por: Lin, Marvin, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_simpvaj2maebc0ne4dtrkken22