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HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice

Hypoxia-inducible factor (HIF)-1 mediates hypoxia- and chronic kidney disease–induced fibrotic events. Here, we assessed whether HIF-1 blockade attenuates the manifestations of diabetic nephropathy in a type 1 diabetic animal model, OVE26. YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole], an H...

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Detalles Bibliográficos
Autores principales:	Nayak, Bijaya K., Shanmugasundaram, Karthigayan, Friedrichs, William E., Cavaglierii, Rita C., Patel, Mandakini, Barnes, Jeffrey, Block, Karen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2016
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839204/ https://www.ncbi.nlm.nih.gov/pubmed/26908870 http://dx.doi.org/10.2337/db15-0519

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