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Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy
PURPOSE: We determined the prevalence of prostatic malignancy in patients undergoing radical cystoprostatectomy (RC) for urothelial carcinoma (UC) with a history of radiation therapy (XRT) treatment for prostatic adenocarcinoma (PCa). MATERIALS AND METHODS: Fifty-three men who underwent a RC for UC...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839230/ https://www.ncbi.nlm.nih.gov/pubmed/27141183 http://dx.doi.org/10.4103/0974-7796.163797 |
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author | Sharma, Pranav Zargar-Shoshtari, Kamran Spiess, Philippe E. Sexton, Wade J. Poch, Michael A. |
author_facet | Sharma, Pranav Zargar-Shoshtari, Kamran Spiess, Philippe E. Sexton, Wade J. Poch, Michael A. |
author_sort | Sharma, Pranav |
collection | PubMed |
description | PURPOSE: We determined the prevalence of prostatic malignancy in patients undergoing radical cystoprostatectomy (RC) for urothelial carcinoma (UC) with a history of radiation therapy (XRT) treatment for prostatic adenocarcinoma (PCa). MATERIALS AND METHODS: Fifty-three men who underwent a RC for UC that were previously treated for PCa with XRT were retrospectively identified. Pathology reports were reviewed to assess for residual PCa or prostatic UC at the time of surgery. RESULTS: Thirteen (25%) patients had residual PCa, 16 (30%) had prostatic UC, and 8 (15%) had both. Sixteen (30%) patients had no evidence of prostatic disease. Patients with PCa had median tumor volume of 2.2 cc (interquartile range: 1.2–2.5 cc) and one-third had high-risk features (Gleason score >8 or pT3-T4 disease). Sixteen of 24 patients (67%) with prostatic UC had a stromal invasion, 5 (21%) had a ductal invasion, and 3 (13%) had carcinoma in situ. Tumors at bladder neck or trigone during transurethral resection were predictive of prostatic UC (odds ratio: 4.32, 95% confidence interval: 1.2–15.5, P = 0.025). CONCLUSIONS: Despite prior XRT for PCa, less than one-third of patients had no prostatic disease at the time of RC. Routine prostatic sampling should be considered in these patients especially if considering the orthotopic diversion. |
format | Online Article Text |
id | pubmed-4839230 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48392302016-05-02 Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy Sharma, Pranav Zargar-Shoshtari, Kamran Spiess, Philippe E. Sexton, Wade J. Poch, Michael A. Urol Ann Original Article PURPOSE: We determined the prevalence of prostatic malignancy in patients undergoing radical cystoprostatectomy (RC) for urothelial carcinoma (UC) with a history of radiation therapy (XRT) treatment for prostatic adenocarcinoma (PCa). MATERIALS AND METHODS: Fifty-three men who underwent a RC for UC that were previously treated for PCa with XRT were retrospectively identified. Pathology reports were reviewed to assess for residual PCa or prostatic UC at the time of surgery. RESULTS: Thirteen (25%) patients had residual PCa, 16 (30%) had prostatic UC, and 8 (15%) had both. Sixteen (30%) patients had no evidence of prostatic disease. Patients with PCa had median tumor volume of 2.2 cc (interquartile range: 1.2–2.5 cc) and one-third had high-risk features (Gleason score >8 or pT3-T4 disease). Sixteen of 24 patients (67%) with prostatic UC had a stromal invasion, 5 (21%) had a ductal invasion, and 3 (13%) had carcinoma in situ. Tumors at bladder neck or trigone during transurethral resection were predictive of prostatic UC (odds ratio: 4.32, 95% confidence interval: 1.2–15.5, P = 0.025). CONCLUSIONS: Despite prior XRT for PCa, less than one-third of patients had no prostatic disease at the time of RC. Routine prostatic sampling should be considered in these patients especially if considering the orthotopic diversion. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4839230/ /pubmed/27141183 http://dx.doi.org/10.4103/0974-7796.163797 Text en Copyright: © Urology Annals http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Sharma, Pranav Zargar-Shoshtari, Kamran Spiess, Philippe E. Sexton, Wade J. Poch, Michael A. Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy |
title | Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy |
title_full | Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy |
title_fullStr | Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy |
title_full_unstemmed | Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy |
title_short | Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy |
title_sort | undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839230/ https://www.ncbi.nlm.nih.gov/pubmed/27141183 http://dx.doi.org/10.4103/0974-7796.163797 |
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