A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage

Whether fibroblasts regulate immune response is a crucial issue in the modulation of inflammatory responses. Herein, we demonstrate that foreskin fibroblasts (FFs) potently inhibit CD3(+) T cell proliferation through a mechanism involving early apoptosis of activated T cells. Using blocking antibodi...

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Detalles Bibliográficos
Autores principales: Dezutter-Dambuyant, Colette, Durand, Isabelle, Alberti, Laurent, Bendriss-Vermare, Nathalie, Valladeau-Guilemond, Jenny, Duc, Adeline, Magron, Audrey, Morel, Anne-Pierre, Sisirak, Vanja, Rodriguez, Céline, Cox, David, Olive, Daniel, Caux, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839348/
https://www.ncbi.nlm.nih.gov/pubmed/27141350
http://dx.doi.org/10.1080/2162402X.2015.1091146

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