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POLE proofreading mutation, immune response and prognosis in endometrial cancer

Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced imm...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: van Gool, Inge C., Bosse, Tjalling, Church, David N.
स्वरूप: Online लेख मूलपाठ
भाषा:English
प्रकाशित: Taylor & Francis 2015
विषय:
ऑनलाइन पहुंच:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839358/
https://www.ncbi.nlm.nih.gov/pubmed/27141333
http://dx.doi.org/10.1080/2162402X.2015.1072675