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Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis

Moment‐based estimators of the between‐study variance are very popular when performing random effects meta‐analyses. This type of estimation has many advantages including computational and conceptual simplicity. Furthermore, by using these estimators in large samples, valid meta‐analyses can be perf...

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Detalles Bibliográficos
Autores principales: Jackson, Dan, Bowden, Jack, Baker, Rose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839498/
https://www.ncbi.nlm.nih.gov/pubmed/26287958
http://dx.doi.org/10.1002/jrsm.1162
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author Jackson, Dan
Bowden, Jack
Baker, Rose
author_facet Jackson, Dan
Bowden, Jack
Baker, Rose
author_sort Jackson, Dan
collection PubMed
description Moment‐based estimators of the between‐study variance are very popular when performing random effects meta‐analyses. This type of estimation has many advantages including computational and conceptual simplicity. Furthermore, by using these estimators in large samples, valid meta‐analyses can be performed without the assumption that the treatment effects follow a normal distribution. Recently proposed moment‐based confidence intervals for the between‐study variance are exact under the random effects model but are quite elaborate. Here, we present a much simpler method for calculating approximate confidence intervals of this type. This method uses variance‐stabilising transformations as its basis and can be used for a very wide variety of moment‐based estimators in both the random effects meta‐analysis and meta‐regression models. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd.
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spelling pubmed-48394982016-04-21 Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis Jackson, Dan Bowden, Jack Baker, Rose Res Synth Methods Original Articles Moment‐based estimators of the between‐study variance are very popular when performing random effects meta‐analyses. This type of estimation has many advantages including computational and conceptual simplicity. Furthermore, by using these estimators in large samples, valid meta‐analyses can be performed without the assumption that the treatment effects follow a normal distribution. Recently proposed moment‐based confidence intervals for the between‐study variance are exact under the random effects model but are quite elaborate. Here, we present a much simpler method for calculating approximate confidence intervals of this type. This method uses variance‐stabilising transformations as its basis and can be used for a very wide variety of moment‐based estimators in both the random effects meta‐analysis and meta‐regression models. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd. John Wiley and Sons Inc. 2015-08-19 2015-12 /pmc/articles/PMC4839498/ /pubmed/26287958 http://dx.doi.org/10.1002/jrsm.1162 Text en © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Jackson, Dan
Bowden, Jack
Baker, Rose
Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis
title Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis
title_full Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis
title_fullStr Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis
title_full_unstemmed Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis
title_short Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis
title_sort approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839498/
https://www.ncbi.nlm.nih.gov/pubmed/26287958
http://dx.doi.org/10.1002/jrsm.1162
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