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Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis
Moment‐based estimators of the between‐study variance are very popular when performing random effects meta‐analyses. This type of estimation has many advantages including computational and conceptual simplicity. Furthermore, by using these estimators in large samples, valid meta‐analyses can be perf...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839498/ https://www.ncbi.nlm.nih.gov/pubmed/26287958 http://dx.doi.org/10.1002/jrsm.1162 |
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author | Jackson, Dan Bowden, Jack Baker, Rose |
author_facet | Jackson, Dan Bowden, Jack Baker, Rose |
author_sort | Jackson, Dan |
collection | PubMed |
description | Moment‐based estimators of the between‐study variance are very popular when performing random effects meta‐analyses. This type of estimation has many advantages including computational and conceptual simplicity. Furthermore, by using these estimators in large samples, valid meta‐analyses can be performed without the assumption that the treatment effects follow a normal distribution. Recently proposed moment‐based confidence intervals for the between‐study variance are exact under the random effects model but are quite elaborate. Here, we present a much simpler method for calculating approximate confidence intervals of this type. This method uses variance‐stabilising transformations as its basis and can be used for a very wide variety of moment‐based estimators in both the random effects meta‐analysis and meta‐regression models. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd. |
format | Online Article Text |
id | pubmed-4839498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48394982016-04-21 Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis Jackson, Dan Bowden, Jack Baker, Rose Res Synth Methods Original Articles Moment‐based estimators of the between‐study variance are very popular when performing random effects meta‐analyses. This type of estimation has many advantages including computational and conceptual simplicity. Furthermore, by using these estimators in large samples, valid meta‐analyses can be performed without the assumption that the treatment effects follow a normal distribution. Recently proposed moment‐based confidence intervals for the between‐study variance are exact under the random effects model but are quite elaborate. Here, we present a much simpler method for calculating approximate confidence intervals of this type. This method uses variance‐stabilising transformations as its basis and can be used for a very wide variety of moment‐based estimators in both the random effects meta‐analysis and meta‐regression models. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd. John Wiley and Sons Inc. 2015-08-19 2015-12 /pmc/articles/PMC4839498/ /pubmed/26287958 http://dx.doi.org/10.1002/jrsm.1162 Text en © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Jackson, Dan Bowden, Jack Baker, Rose Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis |
title | Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis |
title_full | Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis |
title_fullStr | Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis |
title_full_unstemmed | Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis |
title_short | Approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis |
title_sort | approximate confidence intervals for moment‐based estimators of the between‐study variance in random effects meta‐analysis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839498/ https://www.ncbi.nlm.nih.gov/pubmed/26287958 http://dx.doi.org/10.1002/jrsm.1162 |
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