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Curcumin-Loaded PLA Nanoparticles: Formulation and Physical Evaluation

Curcumin is a polyphenolic compound derived from Curcuma domestica (Zingiberaceae) that possesses diverse pharmacological effects including anti-inflammatory, antioxidant, antimicrobial, and anticarcinogenic activities. Although phase I clinical trials have shown curcumin as a safe drug even at high...

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Autores principales: Rachmawati, Heni, Yanda, Yulia L., Rahma, Annisa, Mase, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Austrian Journal of Pharmaceutical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839549/
https://www.ncbi.nlm.nih.gov/pubmed/27110509
http://dx.doi.org/10.3797/scipharm.ISP.2015.10
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author Rachmawati, Heni
Yanda, Yulia L.
Rahma, Annisa
Mase, Nobuyuki
author_facet Rachmawati, Heni
Yanda, Yulia L.
Rahma, Annisa
Mase, Nobuyuki
author_sort Rachmawati, Heni
collection PubMed
description Curcumin is a polyphenolic compound derived from Curcuma domestica (Zingiberaceae) that possesses diverse pharmacological effects including anti-inflammatory, antioxidant, antimicrobial, and anticarcinogenic activities. Although phase I clinical trials have shown curcumin as a safe drug even at high doses (12 g/day) in humans, poor bioavaibility largely limits its pharmacological activity. Nanoencapsulation in biodegradable polymers is a promising alternative to improve curcumin bioavaibility. In this study, curcumin was encapsulated in biodegradable polymer poly-(lactic acid) (PLA) nanoparticles via the emulsification-solvent evaporation method. Optimization of selected parameters of this method including the type of solvent, surfactant concentration, drug loading, sonication time, and centrifugation speed, were performed to obtain polymeric nano-carriers with optimum characteristics. Dichloromethane was used as the solvent and vitamin E polyethylene glycol succinate (TPGS) was used as the surfactant. Four minutes of sonication time and centrifugation at 10500 rpm were able to produce spherical nanoparticles with average size below 300 nm. The highest encapsulation efficiency was found on PLA nanoparticles containing 5% of curcumin at 89.42 ± 1.04%. The particle size, polydispersity index, zeta potential of 5% curcumin-PLA nanoparticles were 387.50 ± 58.60 nm, 0.289 ± 0.047, and −1.12 mV, respectively. Differential Scanning Calorimetry (DSC) and X-Ray Diffraction (XRD) studies showed partial interaction between the drug and polymer.
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spelling pubmed-48395492016-04-22 Curcumin-Loaded PLA Nanoparticles: Formulation and Physical Evaluation Rachmawati, Heni Yanda, Yulia L. Rahma, Annisa Mase, Nobuyuki Sci Pharm Conference Article Curcumin is a polyphenolic compound derived from Curcuma domestica (Zingiberaceae) that possesses diverse pharmacological effects including anti-inflammatory, antioxidant, antimicrobial, and anticarcinogenic activities. Although phase I clinical trials have shown curcumin as a safe drug even at high doses (12 g/day) in humans, poor bioavaibility largely limits its pharmacological activity. Nanoencapsulation in biodegradable polymers is a promising alternative to improve curcumin bioavaibility. In this study, curcumin was encapsulated in biodegradable polymer poly-(lactic acid) (PLA) nanoparticles via the emulsification-solvent evaporation method. Optimization of selected parameters of this method including the type of solvent, surfactant concentration, drug loading, sonication time, and centrifugation speed, were performed to obtain polymeric nano-carriers with optimum characteristics. Dichloromethane was used as the solvent and vitamin E polyethylene glycol succinate (TPGS) was used as the surfactant. Four minutes of sonication time and centrifugation at 10500 rpm were able to produce spherical nanoparticles with average size below 300 nm. The highest encapsulation efficiency was found on PLA nanoparticles containing 5% of curcumin at 89.42 ± 1.04%. The particle size, polydispersity index, zeta potential of 5% curcumin-PLA nanoparticles were 387.50 ± 58.60 nm, 0.289 ± 0.047, and −1.12 mV, respectively. Differential Scanning Calorimetry (DSC) and X-Ray Diffraction (XRD) studies showed partial interaction between the drug and polymer. The Austrian Journal of Pharmaceutical Sciences 2016 2016-02-14 /pmc/articles/PMC4839549/ /pubmed/27110509 http://dx.doi.org/10.3797/scipharm.ISP.2015.10 Text en Copyright: © Rachmawati et al. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Conference Article
Rachmawati, Heni
Yanda, Yulia L.
Rahma, Annisa
Mase, Nobuyuki
Curcumin-Loaded PLA Nanoparticles: Formulation and Physical Evaluation
title Curcumin-Loaded PLA Nanoparticles: Formulation and Physical Evaluation
title_full Curcumin-Loaded PLA Nanoparticles: Formulation and Physical Evaluation
title_fullStr Curcumin-Loaded PLA Nanoparticles: Formulation and Physical Evaluation
title_full_unstemmed Curcumin-Loaded PLA Nanoparticles: Formulation and Physical Evaluation
title_short Curcumin-Loaded PLA Nanoparticles: Formulation and Physical Evaluation
title_sort curcumin-loaded pla nanoparticles: formulation and physical evaluation
topic Conference Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839549/
https://www.ncbi.nlm.nih.gov/pubmed/27110509
http://dx.doi.org/10.3797/scipharm.ISP.2015.10
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