A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus

BACKGROUND: Cyclic acyldepsipeptides (ADEPs) are a novel class of antibacterial agents, some of which (e.g., ADEP 4) are highly active against Gram-positive bacteria. The focus of these in vivo studies is ADEP B315, a rationally designed compound that has the most potent in vitro activity of any ADE...

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Detalles Bibliográficos
Autores principales: Arvanitis, Marios, Li, Gang, Li, De-Dong, Cotnoir, Daniel, Ganley-Leal, Lisa, Carney, Daniel W., Sello, Jason K., Mylonakis, Eleftherios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839560/
https://www.ncbi.nlm.nih.gov/pubmed/27101010
http://dx.doi.org/10.1371/journal.pone.0153912

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