Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners

The supernumerary chromosome 21 in Down syndrome differentially affects the methylation statuses at CpG dinucleotide sites and creates genome-wide transcriptional dysregulation of parental alleles, ultimately causing diverse pathologies. At present, it is unknown whether those effects are dependent...

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Detalles Bibliográficos
Autores principales: Alves da Silva, Antônio Francisco, Machado, Filipe Brum, Pavarino, Érika Cristina, Biselli-Périco, Joice Matos, Zampieri, Bruna Lancia, da Silva Francisco Junior, Ronaldo, Mozer Rodrigues, Pedro Thyago, Terra Machado, Douglas, Santos-Rebouças, Cíntia Barros, Gomes Fernandes, Maria, Chuva de Sousa Lopes, Susana Marina, Lopes Rios, Álvaro Fabricio, Medina-Acosta, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839675/
https://www.ncbi.nlm.nih.gov/pubmed/27100087
http://dx.doi.org/10.1371/journal.pone.0154108

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