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Agreement between Patient and Proxy Assessments of Quality of Life among Older Adults with Vascular Cognitive Impairment Using the EQ-5D-3L and ICECAP-O

BACKGROUND: The assessment of quality of life is critical in ascertaining the benefit of interventions aimed to reduce morbidity among individuals with cognitive impairment. However, the assessment of quality of life is challenging in this population due to the uncertain validity of patient response...

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Autores principales: Davis, Jennifer C., Hsiung, Ging-Yuek, Bryan, Stirling, Jacova, Claudia, Jacova, Patrizio, Munkacsy, Michelle, Cheung, Winnie, Lee, Philip, Liu-Ambrose, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839736/
https://www.ncbi.nlm.nih.gov/pubmed/27101402
http://dx.doi.org/10.1371/journal.pone.0153878
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author Davis, Jennifer C.
Hsiung, Ging-Yuek
Bryan, Stirling
Jacova, Claudia
Jacova, Patrizio
Munkacsy, Michelle
Cheung, Winnie
Lee, Philip
Liu-Ambrose, Teresa
author_facet Davis, Jennifer C.
Hsiung, Ging-Yuek
Bryan, Stirling
Jacova, Claudia
Jacova, Patrizio
Munkacsy, Michelle
Cheung, Winnie
Lee, Philip
Liu-Ambrose, Teresa
author_sort Davis, Jennifer C.
collection PubMed
description BACKGROUND: The assessment of quality of life is critical in ascertaining the benefit of interventions aimed to reduce morbidity among individuals with cognitive impairment. However, the assessment of quality of life is challenging in this population due to the uncertain validity of patient responses as cognitive function declines. Hence, we examined the level of agreement between patient and proxy assessments of health related quality of life (HRQoL) and wellbeing based on the domains that comprise each of these constructs. METHODS: Analysis of baseline data from 71 community-dwelling older adults with mild Vascular Cognitive Impairment (VCI) who participated in a six-month proof-of-concept single-blinded randomized trial. Level of agreement between patient and caregiver ratings of HRQoL (EQ-5D-3L) and wellbeing (ICECAP-O) were compared using raw agreement (%), intraclass correlation coefficient (ICC) and weighted Cohen’s kappa statistic. RESULTS: Self-care (assessed via the EQ-5D-3L) demonstrated almost perfect raw agreement between the patient and caregiver ratings. Three domains (mobility, pain and anxiety) of the EQ-5D-3L demonstrated fair agreement between the patient and caregiver ratings. Two (attachment and control) of the five ICECAP-O domains demonstrated slight agreement. The ICC indicated good agreement for the EQ-5D-3L and poor agreement for the ICECAP-O. CONCLUSION: There is better patient-proxy agreement for the EQ-5D-3L compared with the ICECAP-O among individuals with mild VCI. These findings imply that the ICECAP-O may have limited clinical, research and policy related utility among individuals with mild VCI. TRIAL REGISTRATION: ClinicalTrials.gov NCT01027858
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spelling pubmed-48397362016-04-29 Agreement between Patient and Proxy Assessments of Quality of Life among Older Adults with Vascular Cognitive Impairment Using the EQ-5D-3L and ICECAP-O Davis, Jennifer C. Hsiung, Ging-Yuek Bryan, Stirling Jacova, Claudia Jacova, Patrizio Munkacsy, Michelle Cheung, Winnie Lee, Philip Liu-Ambrose, Teresa PLoS One Research Article BACKGROUND: The assessment of quality of life is critical in ascertaining the benefit of interventions aimed to reduce morbidity among individuals with cognitive impairment. However, the assessment of quality of life is challenging in this population due to the uncertain validity of patient responses as cognitive function declines. Hence, we examined the level of agreement between patient and proxy assessments of health related quality of life (HRQoL) and wellbeing based on the domains that comprise each of these constructs. METHODS: Analysis of baseline data from 71 community-dwelling older adults with mild Vascular Cognitive Impairment (VCI) who participated in a six-month proof-of-concept single-blinded randomized trial. Level of agreement between patient and caregiver ratings of HRQoL (EQ-5D-3L) and wellbeing (ICECAP-O) were compared using raw agreement (%), intraclass correlation coefficient (ICC) and weighted Cohen’s kappa statistic. RESULTS: Self-care (assessed via the EQ-5D-3L) demonstrated almost perfect raw agreement between the patient and caregiver ratings. Three domains (mobility, pain and anxiety) of the EQ-5D-3L demonstrated fair agreement between the patient and caregiver ratings. Two (attachment and control) of the five ICECAP-O domains demonstrated slight agreement. The ICC indicated good agreement for the EQ-5D-3L and poor agreement for the ICECAP-O. CONCLUSION: There is better patient-proxy agreement for the EQ-5D-3L compared with the ICECAP-O among individuals with mild VCI. These findings imply that the ICECAP-O may have limited clinical, research and policy related utility among individuals with mild VCI. TRIAL REGISTRATION: ClinicalTrials.gov NCT01027858 Public Library of Science 2016-04-21 /pmc/articles/PMC4839736/ /pubmed/27101402 http://dx.doi.org/10.1371/journal.pone.0153878 Text en © 2016 Davis et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Davis, Jennifer C.
Hsiung, Ging-Yuek
Bryan, Stirling
Jacova, Claudia
Jacova, Patrizio
Munkacsy, Michelle
Cheung, Winnie
Lee, Philip
Liu-Ambrose, Teresa
Agreement between Patient and Proxy Assessments of Quality of Life among Older Adults with Vascular Cognitive Impairment Using the EQ-5D-3L and ICECAP-O
title Agreement between Patient and Proxy Assessments of Quality of Life among Older Adults with Vascular Cognitive Impairment Using the EQ-5D-3L and ICECAP-O
title_full Agreement between Patient and Proxy Assessments of Quality of Life among Older Adults with Vascular Cognitive Impairment Using the EQ-5D-3L and ICECAP-O
title_fullStr Agreement between Patient and Proxy Assessments of Quality of Life among Older Adults with Vascular Cognitive Impairment Using the EQ-5D-3L and ICECAP-O
title_full_unstemmed Agreement between Patient and Proxy Assessments of Quality of Life among Older Adults with Vascular Cognitive Impairment Using the EQ-5D-3L and ICECAP-O
title_short Agreement between Patient and Proxy Assessments of Quality of Life among Older Adults with Vascular Cognitive Impairment Using the EQ-5D-3L and ICECAP-O
title_sort agreement between patient and proxy assessments of quality of life among older adults with vascular cognitive impairment using the eq-5d-3l and icecap-o
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839736/
https://www.ncbi.nlm.nih.gov/pubmed/27101402
http://dx.doi.org/10.1371/journal.pone.0153878
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