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Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy
OBJECTIVES: This study aimed to clarify whether pretreatment human equilibrative nucleoside transporter (hENT1) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline resectable, and locally advanced unresectable pancr...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839740/ https://www.ncbi.nlm.nih.gov/pubmed/26784908 http://dx.doi.org/10.1097/MPA.0000000000000597 |
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author | Yamada, Reiko Mizuno, Shugo Uchida, Katsunori Yoneda, Misao Kanayama, Kazuki Inoue, Hiroyuki Murata, Yasuhiro Kuriyama, Naohisa Kishiwada, Masashi Usui, Masanobu Ii, Noriko Tsuboi, Junya Tano, Shunsuke Hamada, Yasuhiko Tanaka, Kyosuke Horiki, Noriyuki Ogura, Toru Shiraishi, Taizo Takei, Yoshiyuki Katayama, Naoyuki Isaji, Shuji |
author_facet | Yamada, Reiko Mizuno, Shugo Uchida, Katsunori Yoneda, Misao Kanayama, Kazuki Inoue, Hiroyuki Murata, Yasuhiro Kuriyama, Naohisa Kishiwada, Masashi Usui, Masanobu Ii, Noriko Tsuboi, Junya Tano, Shunsuke Hamada, Yasuhiko Tanaka, Kyosuke Horiki, Noriyuki Ogura, Toru Shiraishi, Taizo Takei, Yoshiyuki Katayama, Naoyuki Isaji, Shuji |
author_sort | Yamada, Reiko |
collection | PubMed |
description | OBJECTIVES: This study aimed to clarify whether pretreatment human equilibrative nucleoside transporter (hENT1) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline resectable, and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those in the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT) and to validate the utility of hENT1 expression using EUS-FNAB samples as a prognostic marker. METHODS: We evaluated the relationship between hENT1 expressions assessed by immunohistochemical staining and clinical outcomes in 51 of 76 patients with PDAC who were diagnosed by EUS-FNAB and received preoperative Gem-CRT. RESULTS: The concordance rate of hENT1 expressions was 89.2% (K = 0.681). Median survival time (month) in the 51 whole patients and 37 patients with resection was significantly longer in hENT1 positive than in hENT1 negative: 25.0 and 30.0 versus 9.0 and 9.0, respectively. A multivariate analysis confirmed that hENT1 expression was an independent prognostic factor in both whole patients and those with resection. Regardless of T3 and T4, hENT1-positive patients with resection had significantly better prognosis than hENT1-negative patients, whose prognosis was similar to those without resection. CONCLUSIONS: The assessment of hENT1 expression using EUS-FNAB samples before Gem-CRT provides important information on patients with PDAC who can benefit from curative-intent resection. |
format | Online Article Text |
id | pubmed-4839740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-48397402016-05-11 Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy Yamada, Reiko Mizuno, Shugo Uchida, Katsunori Yoneda, Misao Kanayama, Kazuki Inoue, Hiroyuki Murata, Yasuhiro Kuriyama, Naohisa Kishiwada, Masashi Usui, Masanobu Ii, Noriko Tsuboi, Junya Tano, Shunsuke Hamada, Yasuhiko Tanaka, Kyosuke Horiki, Noriyuki Ogura, Toru Shiraishi, Taizo Takei, Yoshiyuki Katayama, Naoyuki Isaji, Shuji Pancreas Original Articles OBJECTIVES: This study aimed to clarify whether pretreatment human equilibrative nucleoside transporter (hENT1) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline resectable, and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those in the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT) and to validate the utility of hENT1 expression using EUS-FNAB samples as a prognostic marker. METHODS: We evaluated the relationship between hENT1 expressions assessed by immunohistochemical staining and clinical outcomes in 51 of 76 patients with PDAC who were diagnosed by EUS-FNAB and received preoperative Gem-CRT. RESULTS: The concordance rate of hENT1 expressions was 89.2% (K = 0.681). Median survival time (month) in the 51 whole patients and 37 patients with resection was significantly longer in hENT1 positive than in hENT1 negative: 25.0 and 30.0 versus 9.0 and 9.0, respectively. A multivariate analysis confirmed that hENT1 expression was an independent prognostic factor in both whole patients and those with resection. Regardless of T3 and T4, hENT1-positive patients with resection had significantly better prognosis than hENT1-negative patients, whose prognosis was similar to those without resection. CONCLUSIONS: The assessment of hENT1 expression using EUS-FNAB samples before Gem-CRT provides important information on patients with PDAC who can benefit from curative-intent resection. Lippincott Williams & Wilkins 2016-05 2016-01-18 /pmc/articles/PMC4839740/ /pubmed/26784908 http://dx.doi.org/10.1097/MPA.0000000000000597 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
spellingShingle | Original Articles Yamada, Reiko Mizuno, Shugo Uchida, Katsunori Yoneda, Misao Kanayama, Kazuki Inoue, Hiroyuki Murata, Yasuhiro Kuriyama, Naohisa Kishiwada, Masashi Usui, Masanobu Ii, Noriko Tsuboi, Junya Tano, Shunsuke Hamada, Yasuhiko Tanaka, Kyosuke Horiki, Noriyuki Ogura, Toru Shiraishi, Taizo Takei, Yoshiyuki Katayama, Naoyuki Isaji, Shuji Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy |
title | Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy |
title_full | Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy |
title_fullStr | Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy |
title_full_unstemmed | Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy |
title_short | Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy |
title_sort | human equilibrative nucleoside transporter 1 expression in endoscopic ultrasonography-guided fine-needle aspiration biopsy samples is a strong predictor of clinical response and survival in the patients with pancreatic ductal adenocarcinoma undergoing gemcitabine-based chemoradiotherapy |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839740/ https://www.ncbi.nlm.nih.gov/pubmed/26784908 http://dx.doi.org/10.1097/MPA.0000000000000597 |
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