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Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src

Src family tyrosine kinases (SFKs) phosphorylate caspase-8A at tyrosine (Y) 397 resulting in suppression of apoptosis. In addition, the phosphorylation of caspase-8A at other sites including Y465 has been implicated in the regulation of caspase-8 activity. However, the functional consequences of the...

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Detalles Bibliográficos
Autores principales:	Tsang, Jennifer LY, Jia, Song Hui, Parodo, Jean, Plant, Pamela, Lodyga, Monika, Charbonney, Emmanuel, Szaszi, Katalin, Kapus, Andras, Marshall, John C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839753/ https://www.ncbi.nlm.nih.gov/pubmed/27101103 http://dx.doi.org/10.1371/journal.pone.0153946

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