Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas

Mutational processes and signatures that drive early tumorigenesis are centrally important for early cancer prevention. Yet, to date, biomarkers and risk factors for polyps (adenomas) that inordinately and rapidly develop into colon cancer remain poorly defined. Here, we describe surprisingly high m...

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Detalles Bibliográficos
Autores principales: Chen, Jian, Raju, Gottumukkala S., Jogunoori, Wilma, Menon, Vipin, Majumdar, Avijit, Chen, Jiun-Sheng, Gi, Young Jin, Jeong, Yun Seong, Phan, Liem, Belkin, Mitchell, Gu, Shoujun, Kundra, Suchin, Mistry, Nipun A., Zhang, Jianping, Su, Xiaoping, Li, Shulin, Lin, Sue-Hwa, Javle, Milind, McMurray, John S., Rahlfs, Thomas F., Mishra, Bibhuti, White, Jon, Rashid, Asif, Beauchemin, Nicole, Weston, Brian R., Shafi, Mehnaz A., Stroehlein, John R., Davila, Marta, Akbani, Rehan, Weinstein, John N., Wu, Xifeng, Mishra, Lopa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839765/
https://www.ncbi.nlm.nih.gov/pubmed/27100181
http://dx.doi.org/10.1371/journal.pone.0153933

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