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Microscopic Invasions, Prognoses, and Recurrence Patterns of Stage I Adenocarcinomas Manifesting as Part-Solid Ground-Glass Nodules: Comparison With Adenocarcinomas Appearing as Solid Nodules After Matching Their Solid Parts’ Size

The purpose of the present study was to compare the frequency of microscopic invasions, disease-free-survival (DFS), and the frequency and pattern of disease recurrence between stage I pulmonary adenocarcinomas appearing as solid nodules and those appearing as part-solid ground-glass nodules (GGNs)...

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Autores principales: Hwang, Eui Jin, Park, Chang Min, Kim, Young Tae, Kim, Hyungjin, Goo, Jin Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839866/
https://www.ncbi.nlm.nih.gov/pubmed/27082622
http://dx.doi.org/10.1097/MD.0000000000003419
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author Hwang, Eui Jin
Park, Chang Min
Kim, Young Tae
Kim, Hyungjin
Goo, Jin Mo
author_facet Hwang, Eui Jin
Park, Chang Min
Kim, Young Tae
Kim, Hyungjin
Goo, Jin Mo
author_sort Hwang, Eui Jin
collection PubMed
description The purpose of the present study was to compare the frequency of microscopic invasions, disease-free-survival (DFS), and the frequency and pattern of disease recurrence between stage I pulmonary adenocarcinomas appearing as solid nodules and those appearing as part-solid ground-glass nodules (GGNs) after matching their solid parts’ size (D(solid)) and patients’ age. Among 501 patients who underwent curative surgery for stage I pulmonary adenocarcinomas between 2003 and 2011, 172 patients (86 with solid nodules [M: F = 36: 50; mean age, 62.8 years] and 86 with part-solid GGNs [M:F = 30:56; mean age, 63.0 years]) matched for D(solid) and patients’ age were included. DFS, frequency of microscopic invasions, recurrence, and recurrence pattern were compared between the two groups. No significant difference was observed in the frequency of microscopic invasions between the two groups (visceral pleural invasion, 30.23% vs. 29.07%, P = 0.867; lymphatic invasion, 5.81% vs. 3.49%, P = 0.720; vascular invasion, 1.16% vs. 0%, P = 1.000; solid nodules vs. part-slid GGNs, respectively) and DFS (estimated 5-year DFS, 83.6% vs. 81.9%, P = 0.744; solid nodules vs. part-slid GGNs, respectively). As for recurrence and recurrence pattern, there were no significant differences between the solid nodule group (14/86), and part-solid GGN group (12/86) (P = 0.670). Lung parenchymal nodules were the most frequent pattern of disease recurrence in both groups, followed by pleural seeding. In conclusion, after matching D(solid) and patients’ age, there was no significant difference in the frequency of microscopic invasions, DFS, and the frequency and pattern of recurrence between stage I pulmonary adenocarcinomas appearing as solid nodules and part-solid GGNs.
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spelling pubmed-48398662016-06-02 Microscopic Invasions, Prognoses, and Recurrence Patterns of Stage I Adenocarcinomas Manifesting as Part-Solid Ground-Glass Nodules: Comparison With Adenocarcinomas Appearing as Solid Nodules After Matching Their Solid Parts’ Size Hwang, Eui Jin Park, Chang Min Kim, Young Tae Kim, Hyungjin Goo, Jin Mo Medicine (Baltimore) 6800 The purpose of the present study was to compare the frequency of microscopic invasions, disease-free-survival (DFS), and the frequency and pattern of disease recurrence between stage I pulmonary adenocarcinomas appearing as solid nodules and those appearing as part-solid ground-glass nodules (GGNs) after matching their solid parts’ size (D(solid)) and patients’ age. Among 501 patients who underwent curative surgery for stage I pulmonary adenocarcinomas between 2003 and 2011, 172 patients (86 with solid nodules [M: F = 36: 50; mean age, 62.8 years] and 86 with part-solid GGNs [M:F = 30:56; mean age, 63.0 years]) matched for D(solid) and patients’ age were included. DFS, frequency of microscopic invasions, recurrence, and recurrence pattern were compared between the two groups. No significant difference was observed in the frequency of microscopic invasions between the two groups (visceral pleural invasion, 30.23% vs. 29.07%, P = 0.867; lymphatic invasion, 5.81% vs. 3.49%, P = 0.720; vascular invasion, 1.16% vs. 0%, P = 1.000; solid nodules vs. part-slid GGNs, respectively) and DFS (estimated 5-year DFS, 83.6% vs. 81.9%, P = 0.744; solid nodules vs. part-slid GGNs, respectively). As for recurrence and recurrence pattern, there were no significant differences between the solid nodule group (14/86), and part-solid GGN group (12/86) (P = 0.670). Lung parenchymal nodules were the most frequent pattern of disease recurrence in both groups, followed by pleural seeding. In conclusion, after matching D(solid) and patients’ age, there was no significant difference in the frequency of microscopic invasions, DFS, and the frequency and pattern of recurrence between stage I pulmonary adenocarcinomas appearing as solid nodules and part-solid GGNs. Wolters Kluwer Health 2016-04-18 /pmc/articles/PMC4839866/ /pubmed/27082622 http://dx.doi.org/10.1097/MD.0000000000003419 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 6800
Hwang, Eui Jin
Park, Chang Min
Kim, Young Tae
Kim, Hyungjin
Goo, Jin Mo
Microscopic Invasions, Prognoses, and Recurrence Patterns of Stage I Adenocarcinomas Manifesting as Part-Solid Ground-Glass Nodules: Comparison With Adenocarcinomas Appearing as Solid Nodules After Matching Their Solid Parts’ Size
title Microscopic Invasions, Prognoses, and Recurrence Patterns of Stage I Adenocarcinomas Manifesting as Part-Solid Ground-Glass Nodules: Comparison With Adenocarcinomas Appearing as Solid Nodules After Matching Their Solid Parts’ Size
title_full Microscopic Invasions, Prognoses, and Recurrence Patterns of Stage I Adenocarcinomas Manifesting as Part-Solid Ground-Glass Nodules: Comparison With Adenocarcinomas Appearing as Solid Nodules After Matching Their Solid Parts’ Size
title_fullStr Microscopic Invasions, Prognoses, and Recurrence Patterns of Stage I Adenocarcinomas Manifesting as Part-Solid Ground-Glass Nodules: Comparison With Adenocarcinomas Appearing as Solid Nodules After Matching Their Solid Parts’ Size
title_full_unstemmed Microscopic Invasions, Prognoses, and Recurrence Patterns of Stage I Adenocarcinomas Manifesting as Part-Solid Ground-Glass Nodules: Comparison With Adenocarcinomas Appearing as Solid Nodules After Matching Their Solid Parts’ Size
title_short Microscopic Invasions, Prognoses, and Recurrence Patterns of Stage I Adenocarcinomas Manifesting as Part-Solid Ground-Glass Nodules: Comparison With Adenocarcinomas Appearing as Solid Nodules After Matching Their Solid Parts’ Size
title_sort microscopic invasions, prognoses, and recurrence patterns of stage i adenocarcinomas manifesting as part-solid ground-glass nodules: comparison with adenocarcinomas appearing as solid nodules after matching their solid parts’ size
topic 6800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839866/
https://www.ncbi.nlm.nih.gov/pubmed/27082622
http://dx.doi.org/10.1097/MD.0000000000003419
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