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Virulence factors of Streptococcus pyogenes strains from women in peri-labor with invasive infections
Invasive group A streptococcal (GAS) infections constitute an important epidemiological problem. Many cases occur in women during the postnatal period. The objective of this study was to evaluate the presence of the genes responsible for production of iron-chelating protein (perR) and superantigens...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840219/ https://www.ncbi.nlm.nih.gov/pubmed/26873375 http://dx.doi.org/10.1007/s10096-016-2593-0 |
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author | Golińska, E. van der Linden, M. Więcek, G. Mikołajczyk, D. Machul, A. Samet, A. Piórkowska, A. Dorycka, M. Heczko, P. B. Strus, M. |
author_facet | Golińska, E. van der Linden, M. Więcek, G. Mikołajczyk, D. Machul, A. Samet, A. Piórkowska, A. Dorycka, M. Heczko, P. B. Strus, M. |
author_sort | Golińska, E. |
collection | PubMed |
description | Invasive group A streptococcal (GAS) infections constitute an important epidemiological problem. Many cases occur in women during the postnatal period. The objective of this study was to evaluate the presence of the genes responsible for production of iron-chelating protein (perR) and superantigens (speA, speB, speC, speF, speG, speH, speI, speJ, speK, speL, speM, smeZ, and ssa) in S. pyogenes strains isolated from invasive infections in women after delivery. Furthermore, this study sought to verify whether S. pyogenes strains show special phenotypic and genotypic (sla, spy1325) characteristics that may play a decisive role in adherence to the genital tract epithelium. Moreover, the emm-types and antibiotic susceptibility were determined. We tested 30 invasive S. pyogenes strains isolated from postpartum invasive infection and 37 GAS control strains isolated from the genital tracts of asymptomatic multiparous women. The majority of the tested strains were shown to express two types of emm genes (1 and 28), though emm −12, −28, −75 and −89 were uniquely expressed in the group of strains isolated from invasive infections. A significantly higher prevalence of perR in the strains from puerperal fever was shown. Significant differences were also found between the two groups with respect to the incidence of the genes related to adherence; GAS strains originating from women with sepsis/puerperal fever showed presence of these genes less frequently than those of the control group. Although differences in frequencies of the gene coding for various superantigens were noted between the compared groups of GAS strains, they were not significant. |
format | Online Article Text |
id | pubmed-4840219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-48402192016-05-16 Virulence factors of Streptococcus pyogenes strains from women in peri-labor with invasive infections Golińska, E. van der Linden, M. Więcek, G. Mikołajczyk, D. Machul, A. Samet, A. Piórkowska, A. Dorycka, M. Heczko, P. B. Strus, M. Eur J Clin Microbiol Infect Dis Original Article Invasive group A streptococcal (GAS) infections constitute an important epidemiological problem. Many cases occur in women during the postnatal period. The objective of this study was to evaluate the presence of the genes responsible for production of iron-chelating protein (perR) and superantigens (speA, speB, speC, speF, speG, speH, speI, speJ, speK, speL, speM, smeZ, and ssa) in S. pyogenes strains isolated from invasive infections in women after delivery. Furthermore, this study sought to verify whether S. pyogenes strains show special phenotypic and genotypic (sla, spy1325) characteristics that may play a decisive role in adherence to the genital tract epithelium. Moreover, the emm-types and antibiotic susceptibility were determined. We tested 30 invasive S. pyogenes strains isolated from postpartum invasive infection and 37 GAS control strains isolated from the genital tracts of asymptomatic multiparous women. The majority of the tested strains were shown to express two types of emm genes (1 and 28), though emm −12, −28, −75 and −89 were uniquely expressed in the group of strains isolated from invasive infections. A significantly higher prevalence of perR in the strains from puerperal fever was shown. Significant differences were also found between the two groups with respect to the incidence of the genes related to adherence; GAS strains originating from women with sepsis/puerperal fever showed presence of these genes less frequently than those of the control group. Although differences in frequencies of the gene coding for various superantigens were noted between the compared groups of GAS strains, they were not significant. Springer Berlin Heidelberg 2016-02-12 2016 /pmc/articles/PMC4840219/ /pubmed/26873375 http://dx.doi.org/10.1007/s10096-016-2593-0 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Golińska, E. van der Linden, M. Więcek, G. Mikołajczyk, D. Machul, A. Samet, A. Piórkowska, A. Dorycka, M. Heczko, P. B. Strus, M. Virulence factors of Streptococcus pyogenes strains from women in peri-labor with invasive infections |
title | Virulence factors of Streptococcus pyogenes strains from women in peri-labor with invasive infections |
title_full | Virulence factors of Streptococcus pyogenes strains from women in peri-labor with invasive infections |
title_fullStr | Virulence factors of Streptococcus pyogenes strains from women in peri-labor with invasive infections |
title_full_unstemmed | Virulence factors of Streptococcus pyogenes strains from women in peri-labor with invasive infections |
title_short | Virulence factors of Streptococcus pyogenes strains from women in peri-labor with invasive infections |
title_sort | virulence factors of streptococcus pyogenes strains from women in peri-labor with invasive infections |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840219/ https://www.ncbi.nlm.nih.gov/pubmed/26873375 http://dx.doi.org/10.1007/s10096-016-2593-0 |
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